黄葵胶囊辅助治疗对早期糖尿病肾病患者尿蛋白排泄率和氧化应激的影响  

Effect of adjuvant treatment of Huangkui Capsules on urinary albumin excretion rate and oxidative stress in patients with early diabetic nephropathy

作　　者：何立芳 李青科[1] 薛艳芸[1] 任平香[2] 马玉霞[2] 阎双缓[3] HE Lifang;LI Qingke;XUE Yanyun;REN Pingxiang;MA Yuxia;YAN Shuanghuan(Department of Nephrology,Tangshan People’s Hospital,Hebei Province,Tangshan063000,China;Department of Nephrology,Tangshan Fengrun People’s Hospital,Hebei Province Tangshan064000,China;Department of Infectious Disease,The Fifth Hospital of Shijiazhuang,Hebei Province,Shijiazhuang050000,China)

机构地区：[1]河北省唐山市人民医院肾内科,河北唐山063000 [2]河北省唐山市丰润区人民医院内分泌肾内科,河北唐山064000 [3]石家庄市第五医院感染科,河北石家庄050000

出　　处：《中国医药导报》2023年第12期90-93,共4页China Medical Herald

基　　金：河北省卫生计生委办公室医学科学研究重点课题(20181398)。

摘　　要：目的探讨黄葵胶囊对糖尿病并发早期糖尿病肾病患者尿蛋白排泄率和氧化应激的影响。方法选取2019年12月至2021年12月在河北省唐山市人民医院住院并确诊的糖尿病肾病Ⅳ期患者60例为研究对象,采用随机数字法将其分为对照组及观察组,各30例。两组均接受基础治疗(控制饮食、血糖控制、降压调血脂)。对照组在基础治疗基础上予以缬沙坦80 mg,1次/d;观察组在对照组基础上联合黄葵胶囊2.5 g/次,3次/d,治疗6个月。比较两组临床疗效及治疗前后尿蛋白排泄率(UARE)、血肌酐(SCr)、血β2-微球蛋白(β2-MG)、血超氧化物歧化酶(SOD)、血丙二醛(MDA)、血谷胱甘肽过氧化物酶(GSH-Px)水平。结果观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组UAER、血β2-MG、Scr、MDA均低于治疗前,GSH-PX、SOD均高于治疗前,且观察组UAER、血β2-MG、Scr、MDA低于对照组,GSH-PX、SOD高于对照组,差异有统计学意义(P<0.05)。结论黄葵胶囊辅助治疗可以有效降低患者尿蛋白,其机制可能是通过降低血清MDA,升高血清GSH-Px、SOD,抑制氧化应激,从而发挥肾保护作用。Objective To investigate the effect of Huangkui Capsules on urinary albumin excretion rate and oxidative stress in patients with early diabetic kidney disease.Methods A total of 60 patients with stageⅣdiabetic nephropathy admitted and diagnosed in Tangshan People’s Hospital of Hebei Province from December 2019 to December 2021 were selected as the study objects.They were divided into control group and observation group by random number table method,with 30 cases in each group.The control group was treated with Valsartan 80 mg once a day,and the observation group was treated with Huangkui Capsules three times a day on the basis of the control group,and observed for sie mouths weeks.The clinical efficacy,urinary protein excretion rate(UARE),blood creatinine(SCr),bloodβ2-microglobulin(β2-MG),blood superoxide dismutase(SOD),blood malondialdehyde(MDA)and blood glutathione peroxidase(GSH-Px)before and after treatment were compared between the two groups.Results The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,UAER,bloodβ2-MG,Scr and MDA in two groups were lower than those before treatment,GSH-PX and SOD were higher than before treatment,and UAER,bloodβ2-MG,Scr and MDA in observation group were lower than control group,while GSH-PX and SOD in observation group were higher than control group,the differences were statistically significant(P<0.05).Conclusion Huangkui Capsules adjuvant treatment can effectively reduce the levels of UARE,β2-MG and Scr in patients with diabetic kidney disease.The mechanism may be that Huangkui Capsules can inhibit oxidative stress by reducing serum MDA,and increasing SOD and GSH-PX,so as to exert renal protective effect.

关 键 词：黄葵胶囊 糖尿病肾病 蛋白尿 氧化应激 

分 类 号：R587.24[医药卫生—内分泌]