肝细胞移植的基础研究及临床应用进展  

Progress in basic research and clinical application of hepatocyte transplantation

作　　者：周光鹏 朱志军[1] 孙丽莹[1,2] Zhou Guangpeng;Zhu Zhijun;Sun Liying(Liver Transplantation Center,Clinical Center for Pediatric Liver Transplantation,National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital,Capital Medical University,Beijing 101100,China;Department of Critical Liver Diseases,Liver Research Center,Beijing Friendship Hospital,Capital Medical University,Beijing 101100,China)

机构地区：[1]首都医科大学附属北京友谊医院肝脏移植中心、首都医科大学儿童肝脏移植临床诊疗与研究中心、国家消化系统疾病临床医学研究中心,北京101100 [2]首都医科大学附属北京友谊医院肝病分中心重症肝病科,北京101100

出　　处：《中华肝脏病杂志》2023年第2期216-220,共5页Chinese Journal of Hepatology

基　　金：首都卫生发展科研专项(首发2020-1-2024)。

摘　　要：肝细胞移植被认为是一种很有希望的肝移植的替代治疗方法。虽然肝细胞移植治疗急性肝衰竭和某些遗传代谢性肝病的安全性和有效性已在多项临床试验中得到证实,但是临床肝细胞移植仍面临着诸多的问题和限制,如高质量供体器官短缺、低温保存后细胞活力降低、细胞植入和增殖率低、异体肝细胞排斥反应等。现就肝细胞移植的最新基础研究与临床应用进展进行综述。Hepatocyte transplantation is considered a promising alternative treatment to liver transplantation.Although the safety and efficacy of hepatocyte transplantation in the treatment of acute liver failure and certain inherited metabolic diseases of the liver have been validated in many clinical trials,clinical hepatocyte transplantation still faces many problems and limitations,such as a shortage of high-quality donor organs,reduced cell viability after cryopreservation,low cell implantation and proliferation rates,and allogeneic hepatocyte rejection.This article reviews the latest basic research and clinical application progress in hepatocyte transplantation.

关 键 词：肝细胞移植 急性肝衰竭 遗传代谢性肝病 

分 类 号：R657.3[医药卫生—外科学]