The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China  

作　　者：Yanan Wang Yue Liu Na Lyu Zhiyuan Li Sufang Ma Demin Cao Yuanlong Pan Yongfei Hu Hua Huang George F.Gao Xuebin Xu Baoli Zhu 

机构地区：[1]International Joint Research Center of National Animal Immunology,College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China [2]CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [3]Department of Microbiology,Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China [4]Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100049,China [5]State Key Laboratory of Animal Nutrition,College of Animal Science and Technology,China Agricultural University,Beijing 100193,China [6]Beijing Products Quality Supervision and Inspection Institute,Beijing 101300,China [7]Chinese Center for Disease Control and Prevention(China CDC),Beijing 102206,China [8]Beijing Key Laboratory of Antimicrobial Resistance and Pathogen Genomics,Beijing 100101,China [9]Department of Pathogenic Biology,School of Basic Medical Sciences,Southwest Medical University,Luzhou 646000,China

出　　处：《National Science Review》2023年第3期54-70,共17页国家科学评论（英文版）

基　　金：supported in part by grants from the Major Program of National Natural Science Foundation of China(81991534);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29020203);the Young Top Notch Talents Foundation of Henan Agricultural University(30501278);the Beijing Major Science and Technology Projects(Z201100005520041);the National Key Research and Development Program of China(2018YFC1603900 and2017YFC1600104)。

摘　　要：Salmonella enterica is one of the most common bacterial pathogens in humans and animals.Systematic studies on the trends and geographical distribution of antimicrobial-resistant Salmonella and dominant serovars have been well studied in European and American countries while not in China.Here,taking the One-Health strategy,we used>35000 Salmonella enterica isolates to explore the temporal and spatial dynamics of dominant serovars in China.We found that Salmonella Typhimurium was the dominant serovar causing human infection in China,which was consistent with Australia but inconsistent with North American and European countries.The proportion of Salmonella serovars Typhimurium,London,Rissen,Corvallis,Meleagridis,Kentucky,and Goldcoast showed an increasing trend during 2006-2019.We randomly selected 1962 isolates for comparative genomics and antimicrobial resistance studies and found that the number of antibiotic resistance genes(ARGs)per isolate increased 1.84 and 2.69 times of human and non-human origins,respectively,spanning 14 years.The proportion of antimicrobial-resistant Salmonella isolates had an increasing trend during 2006-2019,especially beta-lactam,quinolone,tetracycline,and rifampicin resistance.Moreover,we found that higher diversity of sequence types(STs)in S.Typhimurium than in other serovars,ST34 from pig and ST 19 from chicken origin,were mainly associated with isolates causing child and adult gastro-infection,respectively.Our results fill in the data gap on the trends of dominant serovars and antimicrobial resistance of Salmonella enterica in China.These data provide useful information for public health decision-makers prioritizing interventions for foodborne diseases and food safety.

关 键 词：salmonella enterica food safety antimicrobial resistance whole-genome sequencing public health 

分 类 号：R446.5[医药卫生—诊断学]