荧光探针用于细胞内硒代半胱氨酸检测的研究进展  

Recent Progress in the Development of Fluorescent Probes for Detection of Intracellular Selenocysteine

作　　者：张姻 赵美 胡婉迪 卢丹青 Zhang Yin;Zhao Mei;Hu Wandi;Lu Danqing(College of Materials Science and Engineering,College of Science,Central South University of Forestry and Technology,Changsha,Hunan 410004,China)

机构地区：[1]中南林业科技大学材料科学与工程学院理学院,湖南长沙410004

出　　处：《化学世界》2023年第2期73-81,共9页Chemical World

基　　金：国家自然科学青年基金(No.22004132);湖南省自然科学基金(No.2020JJ5963);湖南省教育厅科学研究(No.19C1892)资助项目。

摘　　要：硒代半胱氨酸(Sec)在人体调控免疫反应、抑制癌症的发生,以及维持生理氧化还原平衡等方面发挥着十分重要的作用。采用荧光探针直接在分子水平上对硒代半胱氨酸进行体内实时无损检测是探索生理活动机制的最有效的方法。总结了不同类型的荧光探针分子的设计原理及其对应的传感检测机制和成像应用。对比了不同的分析检测方式以及效果,介绍了用于生物硒代半胱氨酸检测的特异性荧光探针的最新进展。Selenocysteine(Sec)plays an important role in regulating the immune response,inhibiting the occurrence of cancer and maintaining the physiological redox balance.The most effective way to explore the mechanism of physiological activity is to use fluorescent probes to detect selenocysteine directly in vivo at the molecular level.The design principles of fluorescent probes and their corresponding sensing detection mechanisms and imaging applications are reviewed.By comparing different detection methods and results,the latest progress of specific fluorescent probes for biological selenocysteine detection is introduced.

关 键 词：荧光探针 硒代半胱氨酸 荧光检测 细胞成像 

分 类 号：O623.736[理学—有机化学]