丹皮酚曼尼希碱衍生物的合成及抗血小板聚集活性  

Synthesis and Anti-Platelet Aggregation Activity of Paeonol Mannich Base Derivatives

作　　者：何冰 戴卫国 尚飞扬 顾宏霞[2] 何黎琴 He Bing;Dai Weiguo;Shang Feiyang;Gu Hongxia;I He Liqin(College of Pharmacy,Anhui University of Chinese Medicine,Hefei,Anhui 230038,China;West Anhui Health Vocational College,Liuan,Anhui 237000,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230038 [2]皖西卫生职业学院,安徽六安237000

出　　处：《化学世界》2023年第2期119-122,共4页Chemical World

基　　金：安徽省教育厅自然科学重点(No.KJ2020A975)资助项目。

摘　　要：以丹皮酚为起始原料,以体积分数为95%乙醇水溶液为溶剂,与多聚甲醛和有机胺经Mannich反应得到得到丹皮酚曼尼希碱衍生物2a~2e。目标化合物2a~2e经红外、核磁共振氢谱和高分辨质谱表证。体外抗血小板聚集活性测试结果表明,所得目标化合物2a~2e对二磷酸腺苷(ADP)和胶原(collagen)所诱导的血小板聚集均具有较强的抑制活性,且明显优于阳性对照药阿司匹林。Five paeonol mannich base derivatives 2a~2e were obtained via Mannich reaction by treating paeonol with various secondary amines and formaldehyde in volume fraction 95%ethanol.The chemical structure of target compounds was confirmed by1H NMR,IR and HR MS,and their anti-platelet aggregation activities were assayed in vitro by born turbidimetry using adenosine diphosphate(ADP)and collagen as inducers.The results showed that 2a~2e can significantly inhibit the platelet aggregation induced by ADP and collagen,and the effect was better than that of aspirin.

关 键 词：丹皮酚 有机胺 曼尼希碱 抗血小板聚集 

分 类 号：R916[医药卫生—药学]