苏州市2011—2020年归因于PM_(2.5)暴露的肺癌早死寿命损失分析  

Premature death and life loss of lung cancer attributed to PM_(2. 5) exposure in Suzhou City from 2011 to 2020

作　　者：吴学飞 陆艳[1] 黄春妍[1] 韦晓淋[1] 王临池[1] 华钰洁 张钧[1] WU Xue-fei;LU Yan;HUANG Chun-yan;WEI Xiao-lin;WANG Lin-chi;HUA Yu-jie;ZHANG Jun(Suzhou Center for Disease Control and Prevention,Jiangsu 215000,China)

机构地区：[1]苏州市疾病预防控制中心,江苏215004

出　　处：《安徽预防医学杂志》2023年第1期10-13,60,共5页Anhui Journal of Preventive Medicine

基　　金：江苏省预防医学科研课题(Y2018032);苏州市科技局民生科技项目(SS201807、SYS2018098、SKYD2022152);苏州市重大疾病、传染病预防和控制关键技术研究(GWZX201901);姑苏卫生人才培养项目(GSWS2019024);苏州市卫生青年骨干人才“全国导师制”项目(Qngg202032)。

摘　　要：目的 分析2011—2020年苏州市归因于室外PM_(2.5)污染的肺癌早死寿命损失。方法 利用2019年全球疾病负担研究(GBD 2019)项目中的中国数据,选择死亡数、死亡率、早死寿命损失年(YLL)和每千人损失寿命年(YLL率)作为分析指标,分析苏州归因于PM_(2.5)的肺癌疾病负担,评估PM_(2.5)国家一级标准(15μg/m^(3))下的肺癌患者健康改善情况。结果 苏州市大气颗粒物PM_(2.5)浓度从2011年的52.15μg/m^(3)下降到2020年的32.61μg/m^(3),下降了37.47%,APC=-6.28%(t=-3.855,P=0.005)。2011—2020年苏州市30岁以上人群因肺癌死亡35 192人,死亡数呈现上升趋势,APC=3.12%(95%CI:2.04%~4.20%,t=5.581,P=0.001)。肺癌死亡率从2011年的61.49/10万上升到2017年的77.86/10万,APC=3.46%(95%CI:2.09%~4.83%,t=4.876,P=0.005),2017年至2020年死亡率逐年下降,但变化趋势无统计学意义(t=-0.933,P=0.525)。2011—2020年苏州市归因于PM_(2.5)的肺癌死亡人数累计11 114例,2011—2017年归因于PM_(2.5)的肺癌死亡人数逐年增加,2017年达到最高峰。归因于PM_(2.5)所致肺癌的YLL为225 239.55人年,YLL率为4.65‰,均为男性显著高于女性;YLL和YLL率在2011—2016年逐年增加,2016年达到最高峰。结论 2011—2020年肺癌对苏州市居民造成严重的疾病负担,归因于PM_(2.5)暴露的肺癌疾病负担在不同性别人群中存在差异。改善空气质量,有助于提高居民健康状况。Objective To analyze the premature death and life loss of lung cancer attributable to outdoor PM_(2.5)pollution in Suzhou city from 2011 to 2020.Methods Based on Chinese data from the Global Burden of Disease Study 2019( GBD 2019), the number of deaths, mortality, years of life lost early( YLL) and years of life lost per 1 000 people( YLL rate) were selected as the analysis indicators to analyze the burden of lung cancer attributable to PM_(2.5)in Suzhou City, and to evaluate the health improvement of lung cancer patients under the PM_(2.5)Level 1 national standard(15 μg/m^(3)).Results The PM_(2.5)concentration decreased by 37. 47% from 52. 15 μg/m^(3) in 2011 to 32. 61 μg/m^(3) in 2020, APC =-6. 28%(t=-3. 855,P=0. 005). There were 35 192 deaths due to lung cancer among people over 30 years old in Suzhou City from 2011 to 2020,and the death rate showed an increasing trend, APC= 3. 12%(95%CI: 2. 04% ~4. 20%,t= 5. 581,P= 0. 001). The mortality rate of lung cancer increased from 61. 49 per 100 000 in 2011 to 77. 86 per 100 000 in 2017, APC = 3. 46%( 95%CI:2. 09% ~4. 83%,t= 4. 876,P= 0. 005). The mortality rate decreased year by year from 2017 to 2020, but the trend was not statistically significant(t=-0. 933,P= 0. 525). The cumulative number of lung cancer deaths attributed to PM_(2.5)in Suzhou City from 2011 to 2020 was 11 114. The number of lung cancer deaths attributed to PM_(2.5)increased year by year from 2011to 2017, peaking in 2017. The YLL of lung cancer attributed to PM_(2.5)was 225 239. 55 person-years, and the YLL rate was 4. 65‰, which was significantly higher in males than that in females. YLL and YLL rate increased year by year from 2011 to 2016, and reached the peak in 2016.Conclusion Lung cancer caused a serious disease burden for Suzhou residents from 2011 to 2020. The burden of lung cancer attributable to PM_(2.5)exposure is different in different gender groups. Improving air quality will help improve the health of residents.

关 键 词：PM_(2.5) 肺癌 YLL YLL率 疾病负担 

分 类 号：R195.4[医药卫生—卫生统计学]