氙气对新生儿缺氧缺血性脑病的神经保护作用及其可能机制  

Neuroprotection and potential mechanism of xenon on neonatal hypoxic-ischemic encephalopathy

作　　者：孙梦雅[1] 李婷[1] 姜红[1] Mengya Sun;Ting Li;Hong Jiang(Department of Neonatology,the Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院新生儿科,青岛266000

出　　处：《中华围产医学杂志》2023年第4期339-343,共5页Chinese Journal of Perinatal Medicine

基　　金：山东省自然科学基金青年项目(ZR2020QH054)。

摘　　要：新生儿缺氧缺血性脑病常引起足月/近足月儿远期不良神经系统预后甚至死亡,且缺乏有效治疗措施。研究表明,氙气可减轻缺氧缺血后脑损伤,可能机制包括拮抗谷氨酸受体、抗凋亡、促进细胞修复和氙气预适应等,具有一定临床应用前景。本文综述氙气在缺氧缺血性脑损伤治疗中的神经保护作用及其机制的研究进展。Neonatal hypoxic-ischemic encephalopathy often causes long-term adverse effect on neurological system or even death in near-term or full-term infants,but no effective treatment is available currently.Studies have shown that xenon can reduce brain injury caused by hypoxia-ischemia and is promising in clinical practice.The possible mechanisms include antagonism to glutamic acid receptors,anti-apoptosis,promotion of cell repair and xenon preconditioning.This article reviews the mechanism and research progress on neuroprotection effect of xenon in the treatment of neonatal hypoxic-ischemic encephalopathy.

关 键 词：氙 缺氧缺血 脑 神经保护 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]