三个有机锡2,2′-联苯二甲酸酯的微波溶剂热合成、结构及体外抗癌活性  

Microwave solvothermal syntheses,crystal structures,and in vitro antitumor activity of three organotin 2,2′-biphenyl dicarboxylate

作　　者：易思佳 贺霞 谷淑琪 邓哲宇 李嘉鸿 庾江喜 张复兴 朱小明 YI Si-Jia;HE Xia;GU Shu-Qi;DENG Zhe-Yu;LI Jia-Hong;YU Jiang-Xi;ZHANG Fu-Xing;ZHU Xiao-Ming(Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province,Key Laboratory of Organometallic New Materials,College of Hunan Province,College of Chemistry and Material Science,Hengyang Normal University,Hengyang,Hunan 421008,China)

机构地区：[1]衡阳师范学院化学与材料科学学院,金属有机新材料湖南省高校重点实验室,功能金属有机化合物湖南省重点实验室,湘江上游重金属污染监测与治理湖南省工程研究中心,衡阳421008

出　　处：《无机化学学报》2023年第5期874-882,共9页Chinese Journal of Inorganic Chemistry

基　　金：湖南省自然科学青年基金(No.2021JJ40010);湖南省教育厅重点项目(No.19A070);湖南省功能金属有机化合物重点实验室开放基金(No.2021HSKFJJ002);湖南省高校科技创新团队支持计划;2020年衡阳市科技局项目(No.202002042081);2022年度湖南省大学生创新创业训练计划一般项目(No.cxcy2022011)资助。

摘　　要：以2,2′-联苯二甲酸(H2DPA)分别与双(三(2-甲基-2-苯基丙基)锡)氧化物、三环己基氢氧化锡和二丁基氧化锡反应,合成了3个有机锡2,2′-联苯二甲酸酯:[((PhC(Me)_(2)CH_(2))_(3)Sn)_(2)(DPA)](1)、[(Cy)_(3)Sn(DPA)]_(n)(2)和[(n-Bu)_(2)Sn(DPA)]_(n)(3)。通过IR、NMR、元素分析、热重及X射线单晶衍射对配合物进行表征分析。配合物1、2、3均属单斜晶系,配合物1为双核结构,配合物2、3为一维链状结构,锡原子的配位数依次增大,分别为4、5、6。体外抗癌活性实验表明,配合物1、2、3对人肺癌细胞(NCI-H460)、人乳腺腺癌细胞(MCF-7)、人肝癌细胞(Hep G2)的增殖具有较强的抑制作用。Three organotin 2,2'-biphenyl dicarboxylates,namely[((PhC(Me)_(2)CH_(2))_(3)Sn)_(2)(DPA)](1),[(Cy)_(3)Sn(DPA)]_(n)(2),and[(n-Bu)_(2)Sn(DPA)]_(n)(3),have been prepared by the microwave-assisted solvothermal reaction of 2,2'-biphenyl dicarboxylic acid(H2DPA)with bis(tri(2-methyl-2-phenyl)propyl)tin oxide,tricyclohexyltin hydroxide,and dibutyltin oxide,respectively.Complexes 1-3 have been characterized by IR,NMR,elemental analysis,and thermogravimetry,and the crystal structures have been determined by X-ray diffraction.The crystals of 1-3 belong to the monoclinic system.Due to the influence of alkyl group steric,the steric resistance of the group for PhC(Me)_(2)CH_(2)(1)>Cy(2)>n-Bu(3),the coordination number of tin atoms of complexes 1-3 increases successively,and the coordination number of tin atoms are 4,5,and 6,respectively.Complex 1 has a binuclear structure,and complexes 2 and 3 are 1D chain structures.The antitumor activity shows that complexes 1-3 have higher activities than cisplatin in Human lung cancer cells(NCI‑H460),human breast adenocarcinoma cells(MCF‑7),and human liver cancer cells(HepG2)line in vitro.CCDC:1966022,1;1966021,2;1966023,3.

关 键 词：有机锡2 2′-联苯二甲酸酯 微波溶剂热合成 晶体结构 体外抗癌活性 

分 类 号：O614.432[理学—无机化学]