Quantification of aflatoxins and health risk assessment through intake of herbal medicine formulations  

作　　者：Shreen D.Nusair Eman Hammad Mohammad AYAlqudah 

机构地区：[1]Department of Clinical Pharmacy,Faculty of Pharmacy,Jordan University of Science and Technology,Irbid,Jordan [2]Department of Forensic Medicine Toxicology and Forensic Sciences,Faculty of Medicine,Jordan University of Science and Technology,Irbid,Jordan [3]Department of Pharmacy Practice and Pharmacotherapeutics,University of Sharjah,Sharjah,United Arab Emirates [4]Faculty of Pharmacy,Jordan University of Science and Technology,Irbid,Jordan

出　　处：《Emerging Contaminants》2023年第1期85-95,共11页新兴污染物（英文）

基　　金：funded by the Deanship of Research at Jordan University of Science and Technology [grant No.20190303].

摘　　要：Aflatoxins(AFs)are frequent contaminants of herbs,which pose a health risk to regular consumers.This study quantified AFs(AFB1,AFB2,AFG1,AFG2,and Total AFs)in 100 of frequently used herbal medicine formulations in Northern Jordan,and assessed the health risk associated with its intake.About half of the samples had levels lower than the detection limit,while the concentrations of AFB1 and Total AFs were higher than the European limits in 10%and 23%of the collected samples,respectively.The mean average daily dose(ADD)of AFB1 through the consumption of the formulations was 3.32×10^(-6)and ranged between 1.21×10^(-9)and 0.00045 ng/kg bwt/day,while the mean ADD of Total AFs was 6.80×10^(-5)and ranged between 3.21×10^(-9)and 0.0015 ng/kg bwt/day.The margin of exposure(MOE)for each medicine herein was far greater than 10,000 as recommended by European Food Safety Authority(EFSA)for carcinogenic and genotoxic substances.Estimated cancer risk due to life time exposure to AFB1 in herbal medicines was 1.03×10^(-5)(ranged between 4.51×10^(-4)to 1.19×10^(-9)cancers/10^(5) individuals/75 year).The frequent occurrence of AFs in the analyzed samples raised questions on their potential harmful consequences on heavy consumers,and suggested that further official measures could minimize contamination and improve management of the associated cancer risk.

关 键 词：Aflatoxin B1 LC-MS/MS Exposure Herbal formulation Health risk Liver cancer 

分 类 号：R288[医药卫生—中药学]