依沙吖啶联合子宫颈扩张单球囊对瘢痕子宫妊娠中期孕妇的影响  

Effect of Ethacridine Combined with Cervical Dilatation Single Balloon on Pregnant Women with Scarred Uterus in the Mid Trimester of Pregnancy

作　　者：马慧冰 MA Huibing(Nanping Maternal and Child Health Hospital,Nanping 353000,China)

机构地区：[1]南平市妇幼保健院,福建南平353000

出　　处：《中外医学研究》2023年第11期108-112,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨依沙吖啶联合子宫颈扩张单球囊对瘢痕子宫妊娠中期孕妇的影响。方法:选取2020年1月—2021年6月在南平市妇幼保健院妇产科引产的82例瘢痕子宫妊娠中期孕妇。根据掷硬币法将其分为对照组和试验组,各41例。对照组采用米非司酮片联合依沙吖啶引产,试验组采用依沙吖啶联合子宫颈扩张单球囊引产。比较两组引产12 h宫颈成熟度,引产效果及清宫率,引产相关指标。比较两组引产前及用药后24 h的人妊娠特异性1糖蛋白(human pregnancy specific 1glycoprotein,SP-1)、胰岛素样生长因子结合蛋白-1(insulin-like growth factor binding protein-1,IGFBP-1)水平。结果:引产12 h,试验组宫颈Bishop评分明显高于对照组,差异有统计学意义(P<0.05)。试验组引产总有效率高于对照组,清宫率显著低于对照组,差异有统计学意义(P<0.05)。试验组宫缩启动时间早于对照组,住院时间短于对照组,产后2 h出血量少于对照组,差异有统计学意义(P<0.05)。用药后24 h,两组SP-1降低,IGFBP-1水平升高,试验组SP-1水平低于对照组,IGFBP-1水平高于对照组,差异有统计学意义(P<0.05)。结论:对于瘢痕子宫妊娠中期孕妇,依沙吖啶联合子宫颈扩张单球囊是一种有效的引产方案,二者联合能提高引产效果,促进产妇宫颈成熟,降低清宫率,减少产后2 h出血量,缩短住院时间,促进患者恢复。Objective:To investigate the effect of Ethacridine combined with cervical dilatation single balloon on pregnant women with scarred uterus in the mid trimester of pregnancy.Method:From January 2020 to June 2021,82 pregnant women with scarred uterus in the mid trimester of pregnancy who were induced labor in the Department of Obstetrics and Gynecology of Nanping Maternal and Child Health Hospital were selected.According to the coin toss method,they were divided into control group and experimental group,41 cases in each group.The control group taken the Mifepristone Tablets combined with Ethacridine for induction of labor,and the experimental group taken the Ethacridine combined with cervical dilatation single balloon for induction of labor.The cervical maturity induced labor for 12 hours,the effect of induction of labor,the rate of uterine clearance,and related indicators of induction of labor were compared between the two groups.Human pregnancy specific 1 glycoprotein(SP-1)and insulin-like growth factor binding protein-1(IGFBP-1)levels before induction of labor and 24 h after medication were compared between the two groups.Result:Induced labor for 12 hours,the cervical Bishop score of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of induction of labor in the experimental group was higher than that in the control group,and the rate of uterine clearance was significantly lower than that in the control group,and the differences were statistically significant(P<0.05).The onset time of uterine contraction in the experimental group was earlier than that in the control group,the hospital stay was shorter than that in the control group,and the amount of bleeding 2 hours after delivery was less than that in the control group,and the differences were statistically significant(P<0.05).At 24 h after medication,SP-1 were decreased and IGFBP-1 levels were increased in the two groups,the SP-1 level of the experiment

关 键 词：依沙吖啶 瘢痕子宫 妊娠中期 引产效果 宫颈成熟 

分 类 号：R719.3[医药卫生—妇产科学]