^(11)C标记的心脏交感神经受体显像剂的研究进展  

Research progress of ^(11)C labeled cardiac sympathetic nerve receptor imaging agents

作　　者：张敏[1] 何玉林[2] 王相成 王雪梅[1] Zhang Min;He Yulin;Wang Xiangcheng;Wang Xuemei(Major of Imaging Medicine and Nuclear Medicine,Inner Mongolia Medical University,Huhhot 010050,China;Department of Nuclear Medicine,Affiliated Hospital of Inner Mongolia Medical University,Huhhot 010050,China;Department of Nuclear Medicine,People's Hospital of Shenzhen,Shenzhen 518020,China)

机构地区：[1]内蒙古医科大学影像医学与核医学专业,呼和浩特010050 [2]内蒙古医科大学附属医院核医学科,呼和浩特010050 [3]深圳市人民医院核医学科,深圳518020

出　　处：《国际放射医学核医学杂志》2023年第2期105-111,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金(81960318);内蒙古自治区科技成果转化专项(2019CG097)。

摘　　要：自主神经系统在调节心血管功能方面起着至关重要的作用,完整的神经支配是心血管功能正常发挥的基础。许多心脏疾病在出现临床症状之前已经出现了神经系统的改变,放射性核素标记的神经递质类似物PET显像可对此进行评估,其可以灵敏地反映心脏自主神经功能的完整性、神经元的分泌功能及活性,以便对心脏疾病进行早期诊断和及时干预。近年来11C标记的心脏交感神经受体显像剂发展迅速,笔者综述了其中几种显像剂的研究新进展。It is crucial that the autonomic nervous system plays a crucial role in regulating cardiovascular function and intact innervation is the basis for normal cardiovascular function.Many cardiac diseases have had neurological alterations before the development of organic lesions,which can be evaluated by PET imaging of radionuclide labeled neurotransmitter analogues.It can sensitively reflect the integrity of cardiac autonomic nervous function,the secretory function and activity of neurons,and provide early diagnosis and timely intervention for cardiovascular disease.In recent years,carbon-11 labeled cardiac sympathetic nerve receptor imaging agents have developed rapidly.The author reviews the new progress of several imaging agents.

关 键 词：碳放射性同位素 自主神经系统 交感神经系统 放射性示踪剂 正电子发射断层显像术 心脏 

分 类 号：R54[医药卫生—心血管疾病] R816.2[医药卫生—内科学]