CT引导下三维插植腔内后装放疗在中晚期子宫颈癌治疗中的效果观察  

Observation on Effect of CT-guided 3D Intracavitary Radiotherapy in the Treatment of Advanced Cervical Cancer

作　　者：叶玲[1] 杨泉富 罗敬[1] YE Ling;YANG Quanfu;LUO Jing(Meizhou People's Hospital,Meizhou 514000,China;不详)

机构地区：[1]梅州市人民医院,广东梅州514000

出　　处：《中外医学研究》2023年第12期32-35,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：梅州市科技计划项目(191205102052535)。

摘　　要：目的:观察CT引导下三维插植腔内后装放疗在中晚期子宫颈癌治疗中的效果。方法:将2016年7月—2020年7月在梅州市人民医院接受根治性放疗的96例中晚期子宫颈癌患者按治疗方法不同分两组,各48例。A组行CT引导下三维插植腔内后装放疗,B组行二维常规腔内后装放疗,同时两组均接受铂类药物化疗。对比两组近期疗效、不良反应,并随访2年对比两组局部控制率、生存率。结果:A组近期总有效率(100.00%)与B组(100.00%)相同,差异无统计学意义(P>0.05)。两组骨髓抑制发生情况比较,差异无统计学意义(P>0.05);A组急性放射性膀胱炎发生率较B组略低,但差异无统计学意义(P>0.05);A组1级、2级急性放射性肠炎发生率(45.83%)较B组(66.67%)更低,差异有统计学意义(P<0.05)。A组随访2年局部控制率较B组略低,生存率较B组略高,但差异均无统计学意义(P>0.05)。结论:CT引导下三维插植腔内后装放疗治疗中晚期子宫颈癌的近期及远期效果均较理想,有助于减少急性放射性肠炎、急性放射性膀胱炎的发生。Objective:To observe the effect of CT-guided 3D intracavitary radiotherapy in the treatment of advanced cervical cancer.Method:A total of 96 patients with advanced cervical cancer who treated with radical radiotherapy in Meizhou People's Hospital from July 2016 to July 2020 were divided into two groups according to therapy,48 patients in each group.Group A was given CT guided 3D intracavitary radiotherapy,group B was given 2D conventional intracavitary radiotherapy,and two groups were given chemotherapy with platinum-based drugs.The short-term effectiveness,adverse reactions of two groups were compared,the local control rate and survival rate between two groups followed up for 2 years were compared.Result:Group A and group B had a same short-term overall response rate(100.00%vs 100.00%),the difference was not statistically significant(P>0.05).There was no significant difference in the incidence of bone marrow suppression between two groups(P>0.05);the incidence of acute radiation cystitis in group A was slightly lower than that in group B,but the difference was not statistically significant(P>0.05);the incidence of grade 1 and 2 acute radiation enteritis in group A(45.83%)was lower than that in group B(66.67%),the difference was statistically significant(P<0.05).During 2-year follow-up,the local control rate in group A was slightly lower than that in group B,and the survival rate was slightly higher than that in group B,but the differences were not statistically significant(P>0.05).Conclusion:CT-guided 3D intracavitary radiotherapy in the treatment of advanced cervical cancer has excellent short-term and long-term effectiveness,it is helpful to reduce the incidences of acute radiation enteritis and acute radiation cystitis.

关 键 词：中晚期子宫颈癌 CT引导 三维插植腔内后装放疗 

分 类 号：R737.33[医药卫生—肿瘤]