小儿热速清颗粒联合注射用阿莫西林钠舒巴坦钠、维生素C治疗小儿急性化脓性扁桃体炎的效果观察  

Observation on Effect of Xiao’er Resuqing Granules Combined with Amoxicillin Sodium and Sulbactam Sodium for Injection,Vitamin C in the Treatment of Acute Suppurative Tonsillitis in Children

作　　者：江秀华 黄丽琴 林贞 JIANG Xiuhua;HUANG Liqin;LIN Zhen(Longyan First Hospital,Longyan 364000,China;不详)

机构地区：[1]龙岩市第一医院,福建龙岩364000

出　　处：《中外医学研究》2023年第12期44-48,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析小儿热速清颗粒联合注射用阿莫西林钠舒巴坦钠、维生素C治疗小儿急性化脓性扁桃体炎的效果。方法:选择龙岩市第一医院2020年5月—2022年5月收治的116例小儿急性化脓性扁桃体炎患者,以治疗方法差异分为对照组与观察组,各58例。对照组采用注射用阿莫西林钠舒巴坦钠联合维生素C注射治疗,观察组在对照组基础上加用小儿热速清颗粒内服治疗。比较两组的临床疗效、中医症候积分、体温变化情况、炎症因子、免疫功能水平及不良反应发生情况。结果:观察组总有效率为91.38%(53/55),高于对照组的77.59%(45/58),差异有统计学意义(P<0.05)。治疗5 d后,两组咽痛、身热乏力、吞咽不利积分均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗5 d后,两组体温均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗5 d后,两组中性粒细胞(NE)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)水平均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗5 d后,两组CD3^(+)/CD45、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)、Th/Ts较治疗前均有所改善,且观察组CD3^(+)/CD45、CD3^(+)CD4^(+)、CD3^(+)CD8^(+)高于对照组,Th/Ts低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为12.07%(7/58),高于对照组的8.62%(5/58),但两组比较差异无统计学意义(P>0.05)。结论:小儿热速清颗粒联合注射用阿莫西林钠舒巴坦钠、维生素C治疗小儿急性化脓性扁桃体炎效果显著,能有效改善症状,降低体温,抑制炎症因子,促进免疫功能恢复,且用药安全可靠。Objective:To analyze the effect of Xiao’er Resuqing Granules combined with Amoxicillin Sodium and Sulbactam Sodium for Injection,Vitamin C in the treatment of acute suppurative tonsillitis in Children.Method:A total of 116 pediatric patients with acute suppurative tonsillitis who admitted to Longyan First Hospital from May 2020 to May 2022 were selected and divided into the control group and the observation group based on differences in treatment methods,58 patients in each group.The control group was treated with Amoxicillin Sodium and Sulbactam Sodium for Injection combined with Vitamin C,while the observation group was treated with oral administration of Xiao’er Resuqing Granules on the basis of the control group.The clinical efficacy,traditional Chinese medicine syndrome scores,body temperature changes,inflammatory factors,immune function levels,and adverse reactions between the two groups were compared.Result:The total effective rate in the observation group was 91.38%(53/55),which was higher than 77.59%(45/58)in the control group,the difference was statistically significant(P<0.05).After 5 d of treatment,the scores of pharyngalgia,body heat and weakness and dysphagia in both groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 5 d of treatment,the temperature of both groups decreased compared with those before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After 5 d of treatment,the levels of neutrophils(NE),hypersensitive C-reactive protein(hs-CRP)and white blood cell count(WBC)in the two groups decreased compared to those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 5 d of treatment,the levels of CD3^(+)/CD45,CD3^(+)CD4^(+),CD3^(+)CD8^(+),Th/Ts in the two groups improved compared to those before treatment,a

关 键 词：急性化脓性扁桃体炎 中医症候 炎症因子 免疫功能 临床疗效 

分 类 号：R766.18[医药卫生—耳鼻咽喉科]