中药内服外洗治疗痛风性关节炎的效果  

Effect of Oral Administration and External Washing of Traditional Chinese Medicine in the Treatment of Gouty Arthritis

作　　者：梁浩华 何灿杰 卢爱梅 LIANG Haohua;HE Canjie;LU Aimei(Guangzhou Panyu District Hospital of Traditional Chinese Medicine,Guangzhou 511400,China;不详)

机构地区：[1]广州市番禺区中医院,广东广州511400

出　　处：《中外医学研究》2023年第12期49-52,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：番禺区科技计划项目(2019-Z04-71)。

摘　　要：目的:探讨中药内服外洗治疗痛风性关节炎(GA)的效果。方法:选取2020年1月—2021年12月广州市番禺区中医院收治的156例GA患者为研究对象。根据入院先后取号并以随机数表法将其分为对照组及观察组,各78例。两组入院后均给予常规处理,对照组给予双氯芬酸钠双释放肠溶胶囊,观察组给予中药内服外洗治疗。比较两组临床疗效,治疗前后关节症状积分、生化指标及不良反应。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组关节疼痛、压痛、肿胀、活动障碍评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血尿酸、C反应蛋白(CRP)、干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗期间不良反应发生率为3.85%,显著低于对照组的12.82%,差异有统计学意义(P<0.05)。结论:中药内服外洗治疗GA的临床效果显著,有助于改善临床症状和炎症反应,降低血尿酸水平,且安全性良好。Objective:To explore the effect of oral administration and external washing of traditional Chinese medicine in the treatment of gouty arthritis(GA).Method:A total of 156 patients with GA who admitted to Guangzhou Panyu District Hospital of Traditional Chinese Medicine from January 2020 to December 2021 were selected as the research object.According to the admission sequence,they were divided into control group and observation group by random number table method,78 cases in each group.Both groups were given routine treatment after admission,the control group was given Diclofenac Sodium Dual Release Enteric-coated Capsules,and the observation group was given oral administration and external washing of traditional Chinese medicine treatment.The clinical efficacy,joint symptom score and biochemical indexes before and after treatment and adverse reactions were compared between two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of joint pain,tenderness,swelling and activity disorder in two groups were lower than those before treatment,the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum uric acid,C-reactive protein(CRP),interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α)in two groups were lower than those before treatment,the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group during treatment was 3.85%,which was significantly lower than 12.82%in the control group,and the difference was statistically significant(P<0.05).Conclusion:The clinical effect of oral administration and external washing of traditional Chinese medicine in the treatment of GA is significant,which helps to improve clinical symptoms and inflamma

关 键 词：中医 痛风性关节炎 生化指标 血尿酸 安全性 

分 类 号：R259[医药卫生—中西医结合]