人参活性成分在防治神经退行性疾病中应用的研究进展  

Research Progress of the Role of Chemical Active Components of Ginseng in Prevention and Treatment of Neurodegenerative Diseases

作　　者：徐维茵 许天阳 邵思梦 谢兆阳 杨洪梅[2] 于澎[1] XU Wei-Yin;XU Tian-Yang;SHAO Si-Meng;XIE Zhao-Yang;YANG Hong-Mei;YU Peng(School of Pharmacy,Changchun University of Traditional Chinese Medicine,Changchun 130117,China;Northeast Asia Institute of Chinese Medicine,Changchun University of Traditional Chinese Medicine,Changchun 130117,China;Centre for Innovation and Practice,Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学药学院,长春130117 [2]长春中医药大学东北亚中医药研究院,长春130117 [3]长春中医药大学创新实践中心,长春130117

出　　处：《应用化学》2023年第4期486-499,共14页Chinese Journal of Applied Chemistry

基　　金：吉林省科技发展计划项目(Nos.20220508086RC,20200708028YY,20220204077YY,20210204035YY,20230203157SF);吉林省卫生技术创新项目(No.2021JC075)资助。

摘　　要：神经退行性疾病是一类由神经系统内特定神经细胞的进程性病变或丢失而导致的神经功能障碍疾病,随着全球人口的老龄化,其发病率呈明显上升趋势。目前,此类疾病的发病机制尚不明确,临床上缺乏有效的治疗措施。人参含有多种活性成分,具有十分广泛的药理功效,在治疗神经退行性疾病中表现出巨大应用潜力。本文总结归纳了人参在神经退行性疾病防治中的活性成分及检测方法;然后,概述了人参在防治神经退行性疾病中的具体药理作用;最后,对其相关机制和通路进行了总结和评述。目前已经发现的具有神经退行性疾病的预防治疗活性的化学成分种类多,但其更多的活性成分及临床应用研究仍有待进一步深入研究。Neurodegenerative disease is a kind of neurological dysfunction disease caused by the progressive lesion or loss of specific nerve cells in the nervous system.With the aging of the global population,its incidence is increasing significantly.At present,the pathogenesis of such diseases is not clear,and there is a lack of effective clinical treatment measures.Ginseng contains a variety of active ingredients and has a very wide range of pharmacological effects in the treatment of neurodegenerative diseases.Based on recent literature reports,this paper first summarizes the active ingredients of ginseng and detection methods.Then,the specific pharmacological effects of ginseng in the prevention and treatment of neurodegenerative diseases are summarized.Finally,the related mechanisms and pathways are summarized and reviewed.At present,there are many kinds of chemical components with preventive and therapeutic activities for neurodegenerative diseases,but more active components and clinical application research still need to be further studied.

关 键 词：人参 神经退行性疾病 活性成分 作用机制 

分 类 号：O629.9[理学—有机化学]