蒙药沙参止咳汤散质量标准提高研究  

Study on the quality standard of Shashen Zhike Decoction Powder

作　　者：王栋 杨非凡 郭宝凤 WANG Dong;YANG Fei-fan;CUO Bao-feng(Inner Mongolia Autonomous Region Drug Inspection and Research Institute,Hohhot 010010,China;Inner Mongolia Autonomous Region,China-Mongolia Medicine Standard Research Key Laboratory,Hohhot 010010,China;Hohhot Inspection and Testing Center,Hohhot 010010,China)

机构地区：[1]内蒙古自治区药品检验研究院,呼和浩特010010 [2]内蒙古自治区中蒙药标准研究重点实验室,呼和浩特010010 [3]呼和浩特市检验检测中心,呼和浩特010010

出　　处：《中国新药杂志》2023年第6期638-642,共5页Chinese Journal of New Drugs

基　　金：《中华人民共和国药典》药品标准提高:沙参止咳汤散项目(49)。

摘　　要：目的:对蒙药沙参止咳汤散的质量标准进行完善和提高。方法:采用TLC法建立拳参、紫草茸的鉴别项,修订甘草鉴别项;采用反相高效液相色谱法建立甘草酸的含量测定项。结果:甘草、拳参、紫草茸薄层鉴别方法斑点清晰,阴性对照无干扰:甘草酸在92.90~1161.25 ng(r=1.0000)范围内呈良好的线性关系,平均回收率为102.5%,RSD为1.85%(n=9)。结论:新建立的方法简单易行、专属性强、稳定性好、重复性好,可用于沙参止咳汤散的质量评价和控制。Objective:To improve the quality standards of Mongolian medicine Shashen Zhike Decoction Powder.Methods:TLC method was used to establish the identification of Bistortae Rhizoma and Shikonin,and the identification of Glycyrrhizae Radix et Rhizoma was revised.The content determination of glycyrrhizic acid was established by reversed phase HPLC.Results:The TLC identification methods resulted in clear spots of Bistortae Rhizoma,Shikonin and Glycyrrhizae Radix Et Rhizoma,without interference for the negative control.Glycyrrhizic acid had good linear relationship in the range from 92.90 to 1161.25 ng(r=0.9999).The average recovery was 102.57%,and the RSD was 1.85%(n=9).Conclusion:The method is simple,specific,stable and repeatable,and can be used for the quality evaluation and control of Shashen Zhike Decoction Powder.

关 键 词：沙参止咳汤散 TLC法 HPLC法 质量标准 

分 类 号：R927.1[医药卫生—药学]