氨磺必联合阿立哌唑治疗精神分裂症的效果及对血清催乳素水平的影响  

Therapeutic efficacy of sulfamethoxazole combined with aripiprazole on schizophrenia and its effect on serum prolactin levels

作　　者：张李婉 陈方斌[1] 蔡占魁 戴冬梅[1] 郑芸 ZHANG Liwan;CHEN Fangbin;CAI Zhankui(Department of Psychiatry,Changzhou Medical District,904th Hospital of the Joint Logistics Support Force of PLA,Jiangsu,Changzhou 213003,China)

机构地区：[1]中国人民解放军联勤保障部队第904医院常州医疗区精神科,江苏省常州市213003

出　　处：《河北医药》2023年第6期841-844,共4页Hebei Medical Journal

摘　　要：目的 探讨联合应用阿立哌唑和氨磺必利治疗精神分裂症的效果及对患者认知功能、催乳素水平、PANSS评分以及血脂代谢变化情况的影响。方法 选2016年9月至2020年9月的精神分裂症患者80例,随机分为对照组和研究组,每组40例。对照组应用氨磺必利,研究组在此基础上应用阿立哌唑。观察2组治疗前后的认知功能情况、阳性和阴性症状量表(PANNSS)评分情况、催乳素水平变化情况、血脂代谢指标[低密度脂蛋白(LDL)、三酰甘油(TG)、高密度脂蛋白(HDL)、总胆固醇(TC)]变化情况、甲状腺素指标[总甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、总三碘甲状腺原氨酸(T3)、游离甲状腺素(FT4)]、肝功能指标[肌酐(SCr)、丙氨酸氨基转移酶(ALT)、天冬氨酸基氨转移酶(AST)]变化情况以及治疗效果、不良反应发生率。结果 研究组治疗后社会认知分,工作记忆分,学习和语言记忆评分分高于对照组(P<0.05);研究组治疗后阴性症状分,阳性症状分,精神病理分,总评分均低于对照组(P<0.05);研究组治疗21、56 d后的催乳素水平均低于对照组(P<0.05);研究组治疗后LDL、TG、TC低于对照组,HDL高于对照组(P<0.05);2组SCr、AST、ALT比较,差异无统计学意义(P>0.05);治疗后研究组T4、FT3、T3、FT4均高于对照组(P<0.05);研究组治疗有效率高于对照组(P<0.05);研究组不良反应总发生率低于对照组(P<0.05)。结论 精神分裂症患者应用阿立哌唑与氨磺必利治疗效果较好,可以改善患者的认知功能和PANSS评分,改善机体的血脂代谢和甲状腺素相关指标水平,且不会损伤患者的肝功能,同时可以提高患者的治疗效果,降低发生不良反应的概率,值得推广应用。Objective To investigate the therapeutic effect of sulfamethoxazole combined with aripiprazole on schizophrenia,and the effect on cognitive function,prolactin level,positive and negative syndrome scale(PANSS),score and changes in blood lipid metabolism.Methods A total of 80 schizophrenia patients admitted from September 2016 to September 2020 were retrospectively recruited.and the patients were randomized 1∶1 to receive sulfamethoxazole(control group)or aripiprazole+sulfamethoxazole(study group).The cognitive function,PANNSS score,prolactin level changes,blood lipid metabolism indexes(low-density lipoprotein[LDL],triacylglycerol[TG],high-density lipoprotein[HDL],total cholesterol[TC]),thyroid function indexes(total thyroxine[T4],free triiodothyronine[FT3],total triiodothyronine[T3],free thyroxine[FT4]),liver function indexes(creatinine[SCr],alanine aminotransferase[ALT],aspartate aminotransferase[AST]),therapeutic efficacy and the incidence of adverse events were compared.Results The scores of social cognition,working memory,learning and language memory in the study group were significantly higher than those in the control group after treatment(P<0.05).The negative symptom scores,positive symptom scores,psychopathological scores,and total scores after treatment were significantly lower in the study group than those of control group(P<0.05).The prolactin levels at 21 and 56 days of treatment were significantly lower in the study group than those of control group(P<0.05).LDL,TG and TC in study group after treatment were significantly lower than those of control group,while HDL was significantly higher(P<0.05).There were no significant differences in SCr,AST,and ALT between the two groups(P>0.05).After treatment,T4,FT3,T3,and FT4 in the study group were significantly higher than those of control group(P<0.05).Significantly higher therapeutic efficacy rate and lower incidence of adverse events were detected in the study group than those of control group(P<0.05).Conclusion Therapeutic efficacy of sulfamethoxazole co

关 键 词：氨磺必利 催乳素 精神分裂症 PANSS评分 阿立哌唑 临床效果 

分 类 号：R971.41[医药卫生—药品]