唑吡坦治疗稳定型心绞痛介入术后合并慢性失眠的临床疗效及预后的影响  

Efficacy of zolpidem in the treatment of chronic insomnia after percutaneous coronary intervention for stable angina pectoris and its effects on cytokines and clinical prognosis

作　　者：张鑫 武芳[1] 赵静 ZHANG Xin;WU Fang;ZHAO Jing(Department of Pharmacy,Urumqi Fourth People's Hospital,Urumqi 830011,China)

机构地区：[1]乌鲁木齐市第四人民医院药剂科,830011

出　　处：《心肺血管病杂志》2023年第4期314-318,共5页Journal of Cardiovascular and Pulmonary Diseases

基　　金：乌鲁木齐市卫生健康委科技计划项目(202126)。

摘　　要：目的:研究唑吡坦治疗稳定型心绞痛经皮冠状动脉介入(percutaneous coronary intervention,PCI)术后合并慢性失眠的疗效及对细胞因子、临床预后的影响。方法:选择2017年1月至2020年12月期间,我院收治并确诊的稳定型心绞痛PCI术后合并慢性失眠患者,随机分为观察组和对照组,分别给予唑吡坦和维生素C治疗,两组患者均持续给药1个月。治疗前及治疗后1个月,采用匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)评价睡眠质量、西雅图心绞痛量表(seattle angina questionnaire,SAQ)评价心绞痛病情,检测外周血TNF-α、IL-1β、IL-6表达;记录治疗期间出现的不良反应,随访治疗后12个月内发生的主要不良心血管事件。结果:治疗后,观察组的各项PSQI评分及外周血TNF-α、IL-1β、IL-6含量均低于对照组(P<0.05),各项SAQ评分与对照组比较差异无统计学意义(P<0.05);治疗期间两组均未出现明显的不良反应,治疗后12个月,观察组的主要不良心血管事件累积发生率均低于对照组(P<0.05)。结论:唑吡坦治疗稳定型心绞痛PCI术后合并慢性失眠显著改善睡眠质量,降低主要不良心血管事件发生,可能与减少炎症细胞因子释放密切相关。Objective:To study the efficacy of zolpidem in the treatment of chronic insomnia after percutaneous coronary intervention(PCI)for stable angina pectoris and its effects on cytokines and clinical prognosis.Methods:Patients with stable angina pectoris complicated with chronic insomnia after PCI in our hospital from January 2017 to December 2020 were selected and randomly divided into the observation group and control group.The observation group and control group were treated with zolpidem and vitamin C,respectively.The Pittsburgh sleep quality index(PSQI)was used to evaluate sleep quality,the Seattle angina questionnaire(SAQ)was used to evaluate the condition of angina pectoris,and the serum cytokines like TNF-α,interleukin 1β(IL-1β)and interleukin 6(IL-6)were detected before and after treatment.The adverse reactions occurred during treatment were recorded,and the major adverse cardiovascular events occurred within 12 months after treatment were followed up.Results:After treatment,the PSQI scores and peripheral blood TNF-α,IL-1βand IL-6 contents of the observation group were lower than those of the control group(P<0.05).There was no statistical difference between the SAQ scores and the control group(P<0.05).There were no obvious adverse reactions in 2 groups during the treatment.12 months after the treatment,the cumulative incidence of major adverse cardiovascular events in the observation group was lower than that in the control group(P<0.05).Conclusions:Zolpidem in the treatment of stable angina pectoris complicated with chronic insomnia after PCI can significantly improve sleep quality and reduce the occurrence of major adverse cardiovascular events,which may be closely related to reducing the release of inflammatory cytokines.

关 键 词：稳定型心绞痛 慢性失眠 唑吡坦 经皮冠状动脉介入术 细胞因子 

分 类 号：R54[医药卫生—心血管疾病]