非编码RNA与围手术期神经认知障碍相关性研究进展  

Research progress on the correlation between non-coding RNA and perioperative neurocognitive disorders

作　　者：孙诗媛 张山[1] Sun Shiyuan;Zhang Shan(Department of Anesthesiology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院麻醉科,石家庄050000

出　　处：《国际麻醉学与复苏杂志》2023年第3期333-336,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：非编码RNA(non-coding RNA,ncRNA)通常作为编码基因的负调节因子在诸多发病机制中起重要作用。围手术期神经认知障碍(perioperative neurocognitive disorders,PND)是老年患者手术后常见并发症之一,严重影响老年患者的生活质量。由于PND潜在分子机制仍不清楚,因此文章主要阐述PND发生过程中ncRNA的作用以及其发挥作用的方式,对预测和治疗PND具有重要意义。Non-coding RNA(ncRNA)often plays an important role in many pathogenic mechanisms as a negative regulator of coding genes.Perioperative neurocognitive disorder(PND)is one of the common post-surgical complications in elderly patients and se-riously affects their quality of life.As the underlying molecular mechanisms of PND are still unclear,this article focuses on the role of ncRNA in the development of PND and the way they function,which are important for the prediction and treatment of PND.

关 键 词：非编码RNA 围手术期神经认知障碍 分子机制 

分 类 号：R614[医药卫生—麻醉学]