基于AHP-CRITIC复合熵权法和响应面法的蛇床子盐炙工艺优选  

Optimization of Processing Technology of Salt-processed Products of Cnidium Fructus Based on Response Surface Method and AHP-CRITIC Mixed Weighting Method

作　　者：袁诗农 王少男 段绪红 郑玉光 YUAN Shi-nong;WANG Shao-nan;DUAN Xu-hong;ZHENG Yu-guang(College of Pharmacy,Hebei University of Chinese Medicine,Shijiazhuang 050200,China;Traditional Chinese Medicine Processing Technology Lnnovation Center of Hebei Province,Shijiazhuang 050200,China;International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province,Shijiazhuang 050200,China;Hebei Chemical and Pharmaceutical College,Shijiazhuang 050030,China)

机构地区：[1]河北中医学院药学院,河北石家庄050200 [2]河北省中药炮制技术创新中心,河北石家庄050200 [3]河北省中药资源利用与质量评价国际联合研究中心,河北石家庄050200 [4]河北化工医药职业技术学院,河北石家庄050026

出　　处：《时珍国医国药》2023年第2期345-350,共6页Lishizhen Medicine and Materia Medica Research

基　　金：河北省中医药管理局科研计划项目(2022099);2022年省属高校基本科研业务费项目(JCYJ2022002)。

摘　　要：目的筛选蛇床子盐炙的最佳炮制工艺参数,为盐蛇床子的质量控制提供实验依据。方法以6个指标成分(花椒毒酚、花椒毒素、佛手柑内酯、王草酚、欧前胡素和蛇床子素)的质量分数和外观性状得分的综合评分为指标,采用层次分析法(AHP)-指标权重确定方法(CRITIC)复合熵权确定各评价指标的权重系数,在单因素试验结果基础上,应用Box-Behnken响应面法考察盐水用量、炒制温度和炒制时间对盐炙蛇床子炮制工艺的影响,筛选蛇床子最佳盐炙工艺参数。结果蛇床子最佳盐炙工艺参数为:每30 g蛇床子,加6 mL食盐水,浸润6 h,于112℃炒制11 min,取出,放凉。结论采用AHP-CRITIC复合熵权法结合Box-Behnken响应面法进行炮制工艺优化,所拟合的模型显著,工艺验证结果合理稳定,可用于蛇床子盐炙最佳工艺的优选,为盐炙蛇床子炮制工艺标准及质量标准的建立提供参考。Objective To screen the best processing parameters of Cnidium Fructus for salt-roasting,and to provide experimental basis for the quality control of salt-roasted Cnidium Fructus.Methods Using the comprehensive score of 6 index components(xanthotoxol,xanthotoxin,bergapten,osthenol,imperatorin and osthole)and appearance score as indicators,the analytic hierarchy process(AHP)was used.-index weight determination method(CRITIC)combined entropy weight to determine the weight coefficient of each evaluation index.On the basis of the single factor test results,the Box-Behnken response surface method was used to investigate the influence of salt water consumption,frying temperature and frying time on salt-roasted snakes.The influence of the processing technology of Cnidium fructus,and the best salt-burning process of Cnidium fructus.Results The optimum salt-baking process parameters of Cnidium moonieri are:add 6 mL of salt water for every 30 g of Cnidium Fructus,soak for 6 h,fry at 112℃for 11 min,take out and let cool.Conclusion The AHP-CRITIC composite entropy weight method combined with the Box-Behnken response surface method is used to optimize the processing process.The fitted model is significant,and the process verification results are reasonable and stable,which can be used for the optimization of the optimal process of Cnidium fructus salt-burning.The optimal processing technology can provide a reference for the establishment of processing technology standards and quality standards of Cnidium fructus salt-roasted.

关 键 词：蛇床子 盐炙 工艺优化 AHP-CRITIC复合熵权 响应面法 

分 类 号：R283[医药卫生—中药学]