GnRH-α联合曼月乐治疗子宫腺肌症患者对血清复发相关指标的影响  

The Effect of GnRH-combined Therapy in Patients with Adenomyosis on Indicators Related to Serum Recurrence

作　　者：王丝雨[1] Wang Siyu(Third People's Hospital,Zhengzhou,Henan Province,450000)

机构地区：[1]郑州市第三人民医院,河南郑州450000

出　　处：《哈尔滨医药》2023年第2期35-37,共3页Harbin Medical Journal

摘　　要：目的分析联合开展GnRH-α(促性腺激素释放激素激动剂)和曼月乐治疗子宫腺肌症患者的效果。方法选取60例子宫腺肌症者为对象,随机数字法分组,即对照组(n=30)、观察组(n=30)。选择行曼月乐治疗对照组;观察组在对照组基础上,加用GnRH-α治疗后者,分析不同方法治疗后取得疗效。结果两组在接受治疗后,相较于对照组,观察组的子宫体积大小、痛经视觉模拟评分(VAS)以及月经失血(PBAC)评分水平均明显更低(P<0.05);血清VEGF、MMP-2MMP-9水平分析,对照组、观察组为对象,前者高于后者,差异有统计学意义(P<0.05);并发症率分析,对照组、观察组为对象,前者高于后者,差异有统计学意义(P<0.05)。结论对于子宫腺肌症,GnRH-a联合曼月乐的治疗效果显著高于曼月乐治疗的效果,能够有效减小子宫体积,降低炎症因子水平,并且控制复发因素的最终效果更好,从而更快促进患者病情状况的恢复。The target of adenomyosis and the combination of GnRH-(gonadotropin-releasing hormone agonist)and Manchester therapy.Methods 60 adenomyoses were selected,namely control group(n=30)and observation group(n=30).Choose the former;on the basis,add GnRH-treat the latter and analyze different methods.Results After treatment,the uterine size,menstrual visual simulation score(VAS)and menstrual blood loss(PBAC)were significantly lower(P<0.05),serum VEGF,MMP-2MMP-9(P<0.05),and complication rate(P<0.05).Conclusion For adenomyosis,the treatment effect of GnRH-a combined with Manchester,is significantly higher than that of Manchester,which can effectively reduce the uterine volume,reduce the level of inflammatory factors,and have the final effect of controlling recurrence factors,so as to promote the recovery of patients'condition faster.

关 键 词：子宫腺肌症 曼月乐治疗 GNRH-A VEGF 炎症因子 

分 类 号：R711.74[医药卫生—妇产科学]