多指标综合评价结合层次分析法探讨防风不同炮制工艺  

To Explore Different Processing Techniques of Fangfeng (Saposhnikoviae Radix) Base on Multi-index Comprehensive Evaluation Combined with Analytic Hierarchy Process

作　　者：王艾琳 谢瑜[1] 王青[1] 聂孝平[1] 谭文波 张文云 WANG Ailin;XIE Yu;WANG Qing;NIE Xiaoping;TAN Wenbo;ZHANG Wenyun(The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha Hunan 410005,China;Changsha Xinlin Pharmaceutical Co.,Ltd.,Changsha Hunan 410203,China)

机构地区：[1]湖南中医药大学第二附属医院,湖南长沙410005 [2]长沙新林制药有限公司,湖南长沙410203

出　　处：《中医药导报》2023年第4期30-34,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省中医药管理局项目(A2022005,D2022137)。

摘　　要：目的:考察防风传统加工中润药工艺及产地趁鲜加工干燥工艺,为提高防风饮片质量提供依据。方法:考察不同产地防风的传统加工及产地趁鲜加工工艺,采用HPLC法测定各防风饮片中升麻素苷、升麻素、5-O-甲基维斯阿米醇苷和亥茅酚苷的含量,通过多指标综合评价结合层次分析法综合加权评分比较防风的不同炮制工艺。结果:防风中升麻素苷、升麻素、5-O-甲基维斯阿米醇苷、亥茅酚苷在一定浓度范围内呈良好的线性关系,相关系数(r)均大于0.999 6;平均加样回收率为98.13%~99.16%,RSD为0.97%~1.33%。传统加工中不同润药方式和鲜药材趁鲜加工后经不同干燥方式所得防风饮片各项指标具有一定差异,防风鲜药材趁鲜加工后冷冻干燥或防风药材经10℃冷水闷润1 h后加工,再经60℃鼓风干燥的炮制工艺较好,其中升麻素苷、升麻素、5-O-甲基维斯阿米醇苷成分能最大程度被保留。结论:该工艺条件可为防风的传统生产及产地趁鲜加工提供参考。Objective:To investigate the moistening technology of traditional processing of Fangfeng(Saposhnikoviae Radix)and the drying technology of fresh processing in the place of origin,so as to provide a basis for improving the quality of Fangfeng(Saposhnikoviae Radix).Methods:The traditional processing and fresh processing techniques of Fangfeng(Saposhnikoviae Radix)from different origins were investigated.The contents of prim-O-glucosylcimifugin,cimifugin,4'-O-beta-Glucopyranosyl-5-O-Methylvisamminol and sec-O-glucosylhamaudol were determined by HPLC.The different processing techniques of Fangfeng(Saposhnikoviae Radix)were compared by multi-index comprehensive evaluation combined with analytic hierarchy process.Results:The linear relationship of prim-O-glucosylcimifugin,cimifugin,4'-O-beta-Glucopyranosyl-5-O-Methylvisamminol and sec-O-glucosylhamaudol in Fangfeng(Saposhnikoviae Radix)was good in a certain concentration range,and the correlation coefficient(r)were all greater than 0.9996.The average recovery was 98.13%-99.16%,RSD was 0.97%-1.33%.There were certain differences in various indicators of the prepared pieces of Fangfeng(Saposhnikoviae Radix)in different moistening methods and different drying methods after fresh cut of fresh medicinal materials in traditional processing.The processing technology of fresh medicinal materials of Fangfeng(Saposhnikoviae Radix)was better,such as freeze-drying after fresh-cutting or soaking in cold water at 10℃for 1 hour,and then drying by air blast at 60℃.The processing technology was better,among which the components of prim-O-glucosylcimifugin,cimifugin,4'-O-beta-Glucopyranosyl-5-O-Methylvisamminol can be retained to the greatest extent.Conclusion:The process conditions can provide reference for the traditional production and fresh processing of Fangfeng(Saposhnikoviae Radix).

关 键 词：防风 产地加工 炮制工艺 层次分析法 含量测定 

分 类 号：R284.1[医药卫生—中药学]