胺碘酮联合门冬氨酸钾镁治疗冠心病快速心律失常的疗效分析  

Efficacy analysis of amiodarone combined with potassium aspartate and magnesium aspartate in treating tachyarrhythmia of coronary heart disease

作　　者：姚佳 YAO Jia(Nuclear Industry General Hospital of Liaoning Health Industry Group,Huludao 125100,China)

机构地区：[1]辽宁省健康产业集团核工业总医院,125100

出　　处：《中国现代药物应用》2023年第7期68-70,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究胺碘酮联合门冬氨酸钾镁治疗冠心病快速心律失常的临床效果。方法52例冠心病快速心律失常患者,随机分为对照组和观察组,各26例。对照组采用常规方法治疗,观察组在常规方法基础上采用胺碘酮联合门冬氨酸钾镁治疗。比较两组临床疗效,治疗前后心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)],不良反应发生情况。结果观察组治疗总有效率92.31%高于对照组的69.23%,差异有统计学意义(P<0.05)。治疗后,观察组LVEDD(49.35±5.53)mm、LVESD(40.43±5.06)mm小于对照组的(55.56±5.69)、(46.42±5.38)mm,LVEF(57.79±4.98)%高于对照组的(48.15±5.35)%,差异有统计学意义(P<0.05)。观察组不良反应发生率19.23%低于对照组的50.00%,差异有统计学意义(P<0.05)。结论胺碘酮联合门冬氨酸钾镁治疗冠心病快速心律失常具有明显的效果,且不良反应较少,值得推广。Objective To investigate the clinical effect of amiodarone combined with potassium aspartate and magnesium aspartate in treating tachyarrhythmia of coronary heart disease.Methods A total of 52 patients with tachyarrhythmias of coronary heart disease were randomly divided into control group and observation group,with 26 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with amiodarone and potassium aspartate and magnesium aspartate on the basis of conventional treatment.Both groups were compared in terms of clinical efficacy,cardiac function indexes[left ventricular enddiastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)]before and after treatment,and the occurrence of adverse reactions.Results The total effective rate of the observation group was 92.31%,which was higher than that of 69.23%in the control group,and the difference was statistically significant(P<0.05).After treatment,LVEDD of(49.35±5.53)mm and LVESD of(40.43±5.06)mm in the observation group were less than those of(55.56±5.69)and(46.42±5.38)mm in the control group;LVEF of(57.79±4.98)%in the observation group was higher than that of(48.15±5.35)%in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 19.23%,which was lower than that of 50.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Amiodarone combined with potassium aspartate and magnesium aspartate has obvious effect in the treatment of tachyarrhythmia of coronary heart disease,and there are few adverse reactions,which is worthy of promotion.

关 键 词：胺碘酮 门冬氨酸钾镁 冠心病 心律失常 

分 类 号：R541.7[医药卫生—心血管疾病] R541.4[医药卫生—内科学]