沙丁胺醇、布地奈德不同雾化吸入联合头孢哌酮钠舒巴坦钠对AECOPD患者血气指标和肺功能的影响  

Effects of different nebulized inhalation of salbutamol and budesonide combined with cefoperazone sodium and sulbactam sodium on blood gas index and lung function in patients with AECOPD

作　　者：王东辉 WANG Dong-hui(Xingcheng People's Hospital,Huludao 125100,China)

机构地区：[1]兴城市人民医院,125100

出　　处：《中国现代药物应用》2023年第7期89-91,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究沙丁胺醇、布地奈德不同雾化吸入联合头孢哌酮钠舒巴坦钠对慢性阻塞性肺疾病急性加重期(AECOPD)患者血气指标和肺功能的影响。方法98例AECOPD患者,随机分为参照组与研究组,各49例。两组患者均实施头孢哌酮钠舒巴坦钠治疗,在此基础上,参照组实施沙丁胺醇、布地奈德持续雾化吸入治疗,研究组实施先沙丁胺醇雾化吸入后布地奈德雾化吸入治疗。比较两组患者治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)]及血气指标[血氧饱和度(SaO2)、动脉血氧分压(PaO2)]水平。结果治疗后,两组患者FVC、FEV1/FVC水平均高于本组治疗前,且研究组患者FVC(2.41±0.41)L、FEV1/FVC(66.40±6.66)%均高于参照组的(2.07±0.23)L、(62.40±5.51)%,差异有统计学意义(P<0.05)。治疗后,两组患者SaO2、PaO2水平均高于本组治疗前,且研究组SaO2(92.38±7.34)%、PaO2(78.86±4.28)mm Hg(1 mm Hg=0.133 kPa)高于参照组的(81.45±6.18)%、(64.38±4.32)mm Hg,差异有统计学意义(P<0.05)。结论AECOPD患者采用先沙丁胺醇雾化吸入后布地奈德雾化吸入联合头孢哌酮钠舒巴坦钠治疗,具有显著效果,可改善患者的肺功能及血气指标,促进患者恢复。Objective To study the effects of different nebulized inhalation of salbutamol and budesonide combined with cefoperazone sodium and sulbactam sodium on blood gas index and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 98 patients with AECOPD were randomly divided into the reference group and the research group,with 49 patients in each group.Both groups were treated with cefoperazone sodium and sulbactam sodium.On this basis,the reference group was treated with salbutamol and budesonide continuous nebulized inhalation,and the research group was treated with salbutamol nebulized inhalation followed by budesonide nebulized inhalation.Both groups were compared in terms of pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in one second to FVC(FEV1/FVC)]and blood gas indexes[oxygen saturation(SaO2),arterial partial pressure of oxygen(PaO2)]levels before and after treatment.Results After treatment,the levels of FVC and FEV1/FVC in both groups were higher than those before treatment in this group;the FVC(2.41±0.41)L and FEV1/FVC(66.40±6.66)%in the research group were higher than(2.07±0.23)L and(62.40±5.51)%in the reference group,and the differences were statistically significant(P<0.05).After treatment,the SaO2 and PaO2 levels in both groups were higher than those before treatment in this group;the SaO2(92.38±7.34)%and PaO2(78.86±4.28)mm Hg(1 mm Hg=0.133 kPa)in the research group were higher than(81.45±6.18)%and(64.38±4.32)mm Hg in the reference group;the differences were statistically significant(P<0.05).Conclusion Salbutamol nebulized inhalation followed by budesonide nebulized inhalation combined with cefoperazone sodium and sulbactam sodium has significant therapeutic effect in the treatment of AECOPD patients,which can improve the pulmonary function,blood gas index,and promote the recovery of patients.

关 键 词：沙丁胺醇 布地奈德 雾化吸入 头孢哌酮钠舒巴坦钠 慢性阻塞性肺疾病急性加重期 

分 类 号：R563.9[医药卫生—呼吸系统]