中药不良反应原因与安全用药管理对策分析  

Analysis of Adverse Reaction Cause of Traditional Chinese Medicine and Safe Medication Management Countermeasures

作　　者：石梅[1] Shi Mei(Taizhou Fourth People's Hospital,Taizhou 225300,Jiangsu Province,China)

机构地区：[1]江苏省泰州市第四人民医院,江苏泰州225300

出　　处：《中外医药研究》2022年第17期6-8,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析中药不良反应(AR)原因,制定相关安全用药管理对策。方法:选取2019年2月—2022年2月江苏省泰州市第四人民医院接受中药处方治疗的1412例患者为研究对象。分析所有患者用药期间AR发生情况、严重程度、原因、中药与AR的因果关系分析。结果:1412例接受中药处方治疗患者中,发生AR 55例,发生率3.90%。AR累及皮肤与附件占45.45%,累及外周与中枢神经系统占29.09%,累及消化系统占12.73%,累及心血管系统占10.91%,累及呼吸系统占1.82%。55例AR患者轻度29.10%、中度65.46%、重度5.45%。剂量失当占41.82%,个体差异占25.45%,药物配伍失当占12.73%,药物本身原因占1.82%,剂型失当占18.18%。中药与AR的因果关系中肯定例数占9.10%,很可能例数占65.45%,可能例数占23.64%,可疑例数占1.82%。结论:中药AR发生原因以剂量失当、个体差异及剂型失当常见。Objective:To analyze the causes of adverse reaction(AR)of traditional Chinese medicine and formulate relevant safe medication management countermeasures.Methods:A total of 1412 patients who received traditional Chinese medicine prescription treatment in Taizhou Fourth People's Hospital of Jiangsu Province from February 2019 to February 2022 were selected as the study subjects.The occurrence,severity and causes of AR in all patients during the medication,as well as the causality of traditional Chinese medicine and AR were analyzed.Results:Among 1412 patients treated with traditional Chinese medicine prescription,55 patients developed AR,with an incidence of 3.90%.The proportions of AR involving skin and appendages,involving peripheral and central nervous system,involving digestive system,involving cardiovascular system and involving respiratory system were 45.45%,29.09%,12.73%,10.91%and 1.82%,respectively.The proportions of mild,moderate and severe AR in patients were 29.09%,65.45%and 5.45%,respectively.The proportions of causes of AR as improper dosage,individual differences,drug incompatibility,drug itself and improper dosage form were 41.82%,25.45%,12.73%,1.82%and 18.18%,respectively.For the causality of traditional Chinese medicine and AR,the number of definite cases accounted for 9.10%,the number of very possible cases accounted for 65.45%,the number of possible cases accounted for 23.64%,and the number of suspicious cases accounted for 1.82%.Conclusion:The common causes of AR in traditional Chinese medicine are improper dosage,individual differences and improper dosage forms.

关 键 词：中药 不良反应 安全用药 管理对策 原因分析 

分 类 号：R28[医药卫生—中药学]