Immunophenotyping identifies distinct cellular signatures for systemic lupus erythematosus and lupus nephritis  

作　　者：Yi Tong V.Aw Phillip J.Whiley Ayla May Lorenzo Tom Lea-Henry Somasundhari Shanmuganandam Maurice Stanley Sonia N.Babu Vicki Athanasopoulos Jean Cappello Julia I.Ellyard Matthew Cook Carola Vinuesa Giles Walters David A.Fulcher Simon H.Jiang 

机构地区：[1]Division of Medicine,The Canberra Hospital,Garran,Australian Capital Territory,Australia [2]The Australian National University Medical School,Garran,Australian Capital Territory,Australia [3]Department of General Surgery,The Canberra Hospital,Garran,Australian Capital Territory,Australia [4]Department of Immunology and Infectious Disease,John Curtin School of Medical Research,Garran,Australian Capital Territory,Australia [5]Centre for Personalized Immunology,NHMRC Centre for Research Excellence,Canberra,Australia [6]Department of Renal Medicine,The Canberra Hospital,Garran,Australian Capital Territory,Australia [7]Department of Immunology,The Canberra Hospital,Canberra,Australian Capital Territory,Australia

出　　处：《Rheumatology & Autoimmunity》2023年第1期15-25,共11页风湿病与自身免疫（英文）

基　　金：The Canberra Hospital Private Practice Fund;National Health and Medical Research Council;The Jacquot Foundation。

摘　　要：Background:Systemic lupus erythematosus(SLE)is a complex systemic autoimmune disease characterized by development of autoantibodies and multiorgan involvement.Kidney involvement,termed lupus nephritis,has major impact on life expectancy.It is increasingly recognized that SLE is likely a common clinical manifestation of pathophysiologically diverse processes,and lupus nephritis has similarly been associated with several distinct immunological processes.We compared the immune cell phenotypes of individuals with SLE in the presence or absence of nephritis.Methods:Cryopreserved peripheral blood mononuclear cells from SLE patients with and without kidney involvement underwent flow cytometric analysis to identify major populations in T cells,B cells and myeloid lineages.Results:We compared the frequencies of lymphocyte populations in 69 SLE patients without nephritis,20 SLE patients with nephritis,and 92 healthy blood donors.Patients with SLE and lupus nephritis(LN)had reduced marginal zone B cells(P<0.0001 in SLE;P=0.001 in LN),memory B cells(P=0.002 in SLE;P=0.001 in LN)and circulating T follicular helper(Tfh)memory cells(P<0.0001 in SLE and LN)compared to healthy donors.Patients with lupus nephritis had increase Th2(P<0.0001)and T regulatory cells(P<0.0001)compared to both SLE patients without nephritis and healthy donors.Conclusion:SLE patients with and without lupus nephritis have distinct immunologic differences that may reflect the unique pathophysiological processes contributing to disease manifestations.

关 键 词：immunoprofiling lupus nephritis systemic lupus erythematosus 

分 类 号：R593.241[医药卫生—内科学]