Phenotypical statin-associated immune-mediated necrotizing myositis with histological features of inclusion body myositis  

作　　者：Nicole Daver Sara Tonini 

机构地区：[1]Overlook Medical Center,Institute for Rheumatic and Autoimmune Diseases,Atlantic Health Systems,Summit,New Jersey,USA

出　　处：《Rheumatology & Autoimmunity》2023年第1期50-55,共6页风湿病与自身免疫（英文）

摘　　要：Introduction:Statin-associated immune-mediated necrotizing myositis(IMNM)is a rare but distinct idiopathic inflammatory myopathy(IIM)that requires early recognition and intervention to prevent irreversible muscle damage.It is typically characterized by active statin use,elevated creatinine kinase(CK)levels,proximal muscle weakness,and at times,a positive 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HMGCR)antibody.Treatment includes immediate discontinuation of the statin and may include corticosteroids,intravenous immunoglobulin(IVIG),and/or immunosuppressive therapy.Inclusion body myositis(IBM),another distinct IIM,also presents with elevated CK levels but with insidious onset of distal upper and proximal lower extremity weakness and is typically refractory to treatment.Case Description:A 64-year-old female patient presented with proximal muscle weakness,elevated CK levels,and a positive HMGCR antibody in the setting of statin use with muscle pathology suggestive of both statinassociated IMNM and IBM.She responded to subcutaneous methotrexate and a slow prednisone taper over several months,however,will require close monitoring for symptoms associated with either disease.Conclusion:In conclusion,we report a case of muscle weakness with muscle pathology demonstrating both statin-associated IMNM and IBM.This case highlights the importance of understanding the clinical and pathological features of statin-associated IMNM and IBM.

关 键 词：3-hydroxy-3-methyl-glutaryl-coenzympe A reductase antibody idiopathic inflammatory myopathy immune-mediated necrotizing myositis inclusion body myositis statin-associated myositis 

分 类 号：R542.2[医药卫生—心血管疾病]