抗膜联蛋白A5抗体与反复妊娠丢失的相关性研究  

The relationship between anti-Annexin A5 antibody and recurrent pregnant loss

作　　者：张洁 蔡珠华 项军淼 郑秀英 陈凤丹 宋展 Zhang Jie;Cai Zhuhua;Xiang Junmiao;Zheng Xiuying;Chen Fengdan;Song Zhan(Department of Obstetrics and Gynecology,Third Affiliated Hospital of Wenzhou Medical University,Ruian 325200,ZheJiang,China)

机构地区：[1]温州医科大学附属第三医院妇产科,浙江瑞安325200

出　　处：《兰州大学学报（医学版）》2023年第3期29-32,38,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：温州市基础性医疗卫生科技资助项目(Y20180276)。

摘　　要：目的 通过检测反复妊娠丢失(RPL)患者血清抗膜联蛋白A5抗体的表达情况,探讨其与RPL的关系,为临床治疗提供理论依据。方法 采用酶联免疫吸附试验法对160例RPL患者、70例健康对照者进行抗膜联蛋白A5抗体检测,分析其在RPL患者中的表达情况,并观察RPL患者妊娠结局、妊娠并发症以及新生儿情况。结果 RPL组的抗膜联蛋白A5抗体的阳性率高于对照组(P <0.05);RPL组的抗膜联蛋白A5抗体水平为(29.95±11.53)ng·mL^(-1),高于对照组的(22.48±9.82)ng·mL^(-1)(P <0.05);2次流产组、3次流产组、4次流产组的抗膜联蛋白A5抗体水平分别为(28.98±11.83)、(31.26±9.52)、(34.70±13.25)ng·mL^(-1),均高于对照组(P<0.05),但不同流产次数组间的抗膜联蛋白A5抗体水平差异无统计学意义(P>0.05);抗膜联蛋白A5抗体阳性组出生体重低于阴性组(P<0.05),其余妊娠结局指标及妊娠并发症方面差异无统计学意义(P>0.05)。结论 抗膜联蛋白A5抗体与RPL关系密切,可作为RPL的危险因素。Objective By detecting the expression of anti-annexin A5 antibody in the serum of patients with recurrent abortion(RPL),the relationship between anti-annexin A5 antibody and RPL was discussed,providing theoretical basis for clinical treatment.Methods Using enzyme-linked immunosorbent assay,160 patients with RPL and 70 healthy controls were tested for anti-annexin A5 antibody,and its expression in RPL patients was analyzed;the pregnancy outcome,complications and neonatal conditions were observed.Results The positive rate of anti-annexin A5 antibody in RPL group was significantly higher than that in the control group(P<0.05);the level of anti-annexin A5 antibody in RPL group(29.95±11.53)ng·mL^(-1) was significantly higher than that in control group(22.48±9.82)ng·mL^(-1)(P<0.05);the levels of anti-annexin A5 antibody in the two abortion groups,three abortion groups and four abortion groups were(28.98±11.83),(31.26±9.52)and(34.70±13.25)ng·mL^(-1),respectively,which were higher than those in the control group,and there was a statistical difference(P<0.05);however,there was no significant difference in the levels of anti-annexin A5 antibody between the groups with different abortion times(P>0.05).The birth weight of the anti-annexin A5 antibody positive group was significantly lower than that of the negative group(P<0.05),and there was no statistically significant difference in other pregnancy outcome indicators and pregnancy complications(P>0.05).Conclusion Anti-annexin A5 antibody is closely related to rcurrent spontaneous abortion and can be used as a risk factor for RPL.

关 键 词：抗膜联蛋白A5抗体 反复妊娠丢失 妊娠结局 

分 类 号：R714.21[医药卫生—妇产科学]