抗菌肽LL-37的生物学活性及其在病毒感染中的发生发展作用  

Biological activities of antimicrobial peptide LL-37 and its role in the development of viral infections

作　　者：何一秀 王梓良 朱亚非[1] HE Yixiu;WANG Ziliang;ZHU Yafei(Department of Pediatrics,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China;Department of Cardiac Surgery,The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]杭州师范大学附属医院儿科,浙江杭州310015 [2]山西医科大学第五临床医学院心外科,山西太原030001

出　　处：《健康研究》2023年第2期202-206,共5页Health Research

基　　金：杭州市科技型中小企业技术创新基金。

摘　　要：LL-37是人体内发现的唯一一种Cathelicidin类抗菌肽,由其前体hCAP-18经丝氨酸蛋白酶3剪切后产生。研究发现,LL-37可在流感病毒、呼吸道合胞病毒、鼻病毒、人类免疫缺陷病毒等病毒中发挥抗病毒作用。文章对LL-37在这些病毒发生发展过程中所起的作用进行综述。LL-37 is the only cathelicidin antimicrobial peptide discovered in humans,which is generated by proteolytic cleavage of its precursor hCAP-18 by serine protease 3.Research has shown that LL-37 exhibits antiviral ability against influenza virus,respiratory syncytial virus,rhinovirus,and human immunodeficiency virus,among others.This article reviews the role of LL-37 in the development of these viral infections.

关 键 词：病毒 抗菌肽 组织蛋白酶抑制素 LL-37 

分 类 号：R725[医药卫生—儿科]