2017-2022年中国HIV感染者高危性行为发生率的Meta分析  

Prevalence of high-risk sexual behavior among HIV-infected individuals in China from 2017-2022:a Meta analysis

作　　者：苏昕怡 肖雪玲[1] 李怡轩 王红红[1] SU Xin-yi;XIAO Xue-ling;LI Yi-xuan;WANG Hong-hong(Xiangya Nursing School,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅护理学院,湖南长沙410013

出　　处：《中国感染控制杂志》2023年第5期552-562,共11页Chinese Journal of Infection Control

基　　金：国家自然科学基金项目(82204169)。

摘　　要：目的 对中国人类免疫缺陷病毒(HIV)感染者的高危性行为发生率进行系统评价,为减少HIV传播和促进该人群健康,制定针对性干预对策提供参考。方法 以艾滋病、高危性行为、HIV、unsafe sex等为主要检索词,在中国知网、万方数据库、中国生物医学文献数据库和PubMed、Web of Science、Embase、the Cochrane Library、CINAHL共8个数据库进行检索,并追溯纳入文献的参考文献,发表时间限定为2017年1月1日-2022年3月31日。计算各类高危性行为的合并发生率及95%置信区间,对无保护性行为进行亚组分析,采用χ^(2)检验推断组间差异。结果 共纳入22篇中文文献,8篇英文文献,总样本量19 764例,覆盖全国17个省(市、自治区)。Meta分析结果显示,中国HIV感染者各类高危性行为的发生率及95%置信区间为:无保护性行为39.7%(33.8%~45.5%)、多性伴43.3%(24.4%~62.2%)、临时性行为27.2%(15.3%~39.1%)、商业性行为14.7%(9.1%~20.2%)。基于数据对该人群无保护性行为进行亚组分析,发现不同性别、年龄、学历、婚姻状况、性行为类型、地区、调查时间,是否进行抗病毒治疗,固定性伴是否感染,各组HIV感染者无保护性行为发生率比较,差异均存在统计学意义(均P<0.05)。结论 中国HIV感染者高危性行为发生率较高,需对包括中老年、未接受抗病毒治疗等无保护性行为发生率较高的感染者进行重点干预,同时探索地域差异的原因,以便制定更具针对性的预防策略。Objective To systematically evaluate the incidence of high-risk sexual behaviors among human immunodeficiency virus(HIV)infected individuals in China,provide reference for developing targeted interventions to reduce HIV transmission and promote the health of this population.Methods Eight databases including CNKI,Wanfang Database,SinoMed,PubMed,Web of Science,Embase,the Cochrane Library and CINAHL were retrieved with key words of“AIDS”,“high-risk sexual behavior”,“HIV”,and“unsafe sex”.The references of included lite-ratures were also traced.Publication date was limited from January 1,2017 to March 31,2022.The pooled incidences and 95%confidence intervals of various types of high-risk sexual behaviors were calculated.Subgroup analysis on unprotected sexual behaviors was conducted,and differences among groups were inferred with χ^(2) test.Results A total of 22 Chinese literatures and 8 English literatures were included,with a total sample size of 19764 individuals,covering 17 provinces(municipalities and autonomous regions)in China.Meta-analysis results showed that the incidences and 95%confidence intervals of various types of high-risk sexual behaviors among HIV-infected individuals in China were 39.7%(33.8%-45.5%)for unprotected sex,43.3%(24.4%-62.2%)for multiple sexual partners,27.2%(15.3%-39.1%)for casual sex,and 14.7%(9.1%-20.2%)for commercial sex.Based on the data,subgroup analysis on unprotected sex in this population revealed that the incidences of unprotec-ted sex among different subgroups,including different gender,age,education,marital status,type of sexual beha-vior,region,survey time,antiviral therapy,and infection status of regular sexual partners,were all significantly different(all P<0.05).Conclusion The incidence of high-risk sexual behaviors among HIV-infected individuals is high.It is necessary to focus on the interventions to those with a high incidence of unprotected sex,including the middle-aged and elderly individuals and individuals without antiviral therapy.Meanwhile,the cau

关 键 词：艾滋病 人类免疫缺陷病毒 高危性行为 荟萃分析 

分 类 号：R512.91[医药卫生—内科学]