人腺病毒致病机制研究进展  

Research progress on the pathogenic mechanism of human adenovirus

作　　者：郑锐林 吴乾龙[1] 陈丹阳 苏静瑶 宁志辉 刘霞[1] 赵明奇 李英华 朱冰[1] ZHENG Rui-lin;WU Qian-long;CHEN Dan-yang;SU Jing-yao;NING Zhi-hui;LIU Xia;ZHAO Ming-qi;LI Ying-hua;ZHU Bing(Central Laboratory,Guangzhou Women and Children’s Medical Center Affiliated to Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]广州医科大学附属广州市妇女儿童医疗中心中心实验室,广东广州510120

出　　处：《中国感染控制杂志》2023年第5期612-620,共9页Chinese Journal of Infection Control

摘　　要：腺病毒(AdV)在自然界分布广泛,全球各国家或地区均有AdV感染出现。科学家于1953年初分离出AdV至今,已发现100多种血清型,可分成哺乳动物AdV和禽类AdV两属。依据AdV抗血清中和的能力,可将人腺病毒(HAdV)分成71种不同的血清型;结合生物学和免疫学特性又将其划分为A~G 7个亚群。AdV可感染上呼吸道、肺、结膜、泌尿道和胃肠道,引起相应部位的炎症,少数则表现为肝炎、胰腺炎、肾炎、出血性结肠炎、出血性膀胱炎、脑膜脑炎,在免疫功能低下的患者常可引起严重甚至致死性感染,因此对人类的健康造成了极大的威胁。本文以HAdV对机体的致病展开综述,讨论了AdV对人体致病的多种作用机制,并提出对HAdV未来致病机制与免疫逃逸研究的展望,并根据其新兴研究提出对新型抗HAdV药物开发的展望。Adenovirus(AdV)is widely distributed in nature,and infections caused by AdV have been reported in countries or regions all over the world.Since AdV was first isolated in 1953,over 100 serotypes have been identified and classified into mammalian AdV and avian AdV.According to the ability to neutralize AdV in serum,human ade-novirus(HAdV)can be further classified into 71 serotypes,which can be divided into 7 subgroups(A-G)based on biological and immunological characteristics.AdV can infect the upper respiratory tract,lung,conjunctiva,urinary tract and gastrointestinal tract,causing inflammation in the corresponding sites.In some cases,AdV can cause he-patitis,pancreatitis,nephritis,hemorrhagic colitis,hemorrhagic cystitis,and meningoencephalitis.AdV can also cause severe or even fatal infections in immunocompromised patients,posing a significant threat to human health.This article reviews the pathogenicity of HAdV in human body and discusses the various mechanisms by which HAdV causes disease.It also proposes future directions for the researches on the pathogenic mechanism and immune escape of HAdV,and outlines prospects for the development of new drugs against HAdV based on emerging research in this field.

关 键 词：人腺病毒 腺病毒 致病机制 综述 

分 类 号：R511.8[医药卫生—内科学]