儿童白癜风患者的血清同型半胱氨酸水平与疾病进展相关  

Serum homocysteine levels are associated with progression of childhood vitiligo

作　　者：张恒坡[1] 常海燕[1] 张大雷[1] 郝伟丽[1] 曹冰青[1] 李静[1] 杜军波 李韵[1] ZHANG Hengpo;CHANG Haiyan;ZHANG Dalei;HAO Weili;CAO Bingqin;LI Jing;DU Junbo;LI Yun(Anyang District Hospital of Puyang City,Anyang 455000,China)

机构地区：[1]濮阳市安阳地区医院,河南安阳455000

出　　处：《皮肤性病诊疗学杂志》2023年第2期146-149,共4页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：濮阳市科技计划项目(010444)。

摘　　要：目的探讨儿童白癜风患者血清同型半胱氨酸(Hcy)水平的检测意义及其与病情的相关性。方法纳入164例儿童白癜风患者,检测其血清同型半胱氨酸水平,并与164例健康体检者进行比较。将患儿分为稳定期与进展期组、快速进展期与非快速进展期组,比较各组Hcy水平,用受试者工作特征(ROC)曲线确定其预测效能。对快速进展期患者治疗后再检测Hcy水平,并与治疗前进行比较。结果儿童白癜风组Hcy水平为27.10±14.30,较健康对照组(9.03±3.54)明显升高,差异有统计学意义(t=15.71,P<0.001)。进展期患者Hcy水平为(35.89±14.70),较稳定期组(17.86±5.13)明显升高,差异有统计学意义(t=10.38,P<0.001)。Hcy在儿童白癜风判断进展期中的效能ROC曲线下面积为0.94(95%CI:0.89~0.97,Z=27.07,P<0.05)。具有最佳预测效能的Hcy截点为22.40,敏感度为90.48%,特异度为82.50%。快速进展期组Hcy水平为55.36±15.86,较非快速进展期组(30.20±8.01)明显升高,差异有统计学意义(t=9.40,P<0.001)。治疗前Hcy水平为35.89±14.70,治疗后(8.35±3.24)明显降低,差异有统计学意义(t=16.76,P<0.001)。结论血清Hcy水平与儿童白癜风的疾病进展有一定相关性,对其病情进展有一定的预测价值。Objective To investigate the significance of serum homocysteine(Hcy)levels and their association with disease state in childhood vitiligo.Methods Serum Hcy levels were measured in 164 childhood vitiligo and 164 healthy controls.Vitiligo subjects were grouped into stable,progressive,rapid progressive and non-rapid progressive groups,and serum Hcy levels were compared among these groups.The receiver operating characteristic(ROC)curve was applied to estimate the predictive efficacy of these parameters.Results Hcy levels were significantly higher in patients with vitiligo than in healthy controls(t=15.71,P<0.001).Hcy levels were significantly higher in progressive vitiligo than in stable vitiligo(35.89±14.70 vs 17.86±5.13,t=10.38,P<0.001).The area under ROC curve(AUC)of Hcy was 0.94,and the optimal cut-off point of Hcy levels was 22.40 in patients with progressive vitiligo,with the sensitivity and specificity of 90.48%and 82.50%,respectively.Hcy levels were significantly higher in patients with rapid progression than in those with non-rapid progression(t=9.40,P<0.001).Hcy levels were lower after the treatment vs baseline levels(8.35±3.24 vs 35.89±14.70,t=16.76,P<0.001).Conclusions Serum Hcy levels are associated with the progression of vitiligo in children.Hcy levels are a potential predictor for the progression of vitiligo.

关 键 词：白癜风 儿童 同型半胱氨酸 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]