大疱性硬斑病1例  

A case of bullous morphea

作　　者：胡强 常建民 HU Qiang;CHANG Jianmin(Graduate University of Peking Union Medical College Hospital;Beijing Hospital,Beijing 100730,China)

机构地区：[1]北京协和医学院研究生院 [2]北京医院,北京100730

出　　处：《皮肤性病诊疗学杂志》2023年第2期154-157,共4页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：报告1例大疱性硬斑病。患者男,69岁,因后背部出现硬斑1年余就诊。皮肤科检查:后背见一硬币大小红色斑块,中央萎缩,边缘隆起,少许出血、结痂,触之质硬。皮损组织病理检查:表皮萎缩,表皮下水疱形成,真皮浅层水肿。真皮全层胶原纤维增生、致密。胶原纤维束间、血管周围炎症细胞浸润。Van Gieson胶原纤维特殊染色及弹力纤维特殊染色显示,真皮网状层弹力纤维无明显减少。诊断:大疱性硬斑病。治疗:口服复方甘草酸苷片,每天3次,每次2片;外用1%吡美莫司乳膏,每天2次。治疗3个月后,电话随访患者背部硬斑软化,无新发皮损。A 69-year-old man presented with a firm plaque on the back for one year.Physical examination revealed a coin-sized red scaly plaque on the back with atrophic center and elevated borders.Bleeding and crusts were visible.Histopathology showed epidermal atrophy,formation of subepidermal blister,superficial dermal edema and increased amount and density of collagen fibers in the dermis.Infiltration of inflammatory cells was observed between collagen fiber bundles and perivessels.The diagnosis was bullous morphea.The skin lesion was improved after 3-month treatments with compound glycyrrhizin tablets and 1%pimecrolimus cream.

关 键 词：硬斑病 大疱性 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]