注射用红花黄色素对大鼠颈总动脉血流动力学的影响及体外溶栓作用  

Effect of safflor yellow injection on hemodynamics of common carotid artery in rats and thrombolysis in vitro

作　　者：刘雅楠 牛芬溪 郑晓春 张硕峰[1] 方芳[1] LIU Ya-nan;NIU Fen-xi;ZHENG Xiao-chun;ZHANG Shuo-feng;FANG Fang(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102400)

机构地区：[1]北京中医药大学中药学院,北京102400

出　　处：《中南药学》2023年第4期968-972,共5页Central South Pharmacy

摘　　要：目的观察注射用红花黄色素(SYI)对大鼠颈总动脉血流量、血压和血流阻力的影响及其体外溶栓作用。方法正常SD大鼠分别静脉给予不同浓度的SYI,采用超声多普勒血流仪和MP150生理记录仪监测给药前及给药后30、60、90和120 min时颈总动脉血流量和血压,计算血流阻力。称重法观察不同浓度SYI对体外血凝块的溶解作用。结果与给药前比较,SYI(0.2 mg·m^(-1))在给药60~120 min时,SYI(0.4 mg·m^(-1))在给药30~60 min时均能明显增加颈总动脉血流量,降低血流阻力,两者在给药120 min时均有降低血压的作用,SYI(0.2 mg·m^(-1))作用更显著。与对照组比较,SYI(0.4 mg·m^(-1))在给药120 min时,能显著降低血压,SYI(0.5 mg·mL^(-1))可以显著增强体外血凝块的溶解作用。结论SYI具有增加大鼠颈总动脉血流量,降低血流阻力和血压及体外溶解血栓的作用。Objective To observe the effect of safflor yellow injection(SYI)on the blood flow,blood pressure and blood flow resistance of the carotid artery communis in normal rats and its thrombolytic effect in vitro.Methods The blood flow and blood pressure of the carotid artery communis were monitored by ultrasound doppler flowmeter and MP150 physiological recorder at 30,60,90 and 120 min after the intravenous administration of different concentrations of SYI in normal SD rats,and the blood flow resistance was calculated.The effect of different concentrations of SYI on the dissolution of blood clots in vitro was observed by weighing method.Results Compared with before the administration,SYI(0.2 mg·mL^(-1))significantly increased the blood flow of carotid artery communis and reduced the blood flow resistance at 60~120 min after the administration.SYI(0.4 mg·mL^(-1))significantly increased the blood flow of carotid artery communis and reduced the blood flow resistance at 30~60 min after the administration.SYI decreased the blood pressure at 120 min after the administration,and SYI(0.2 mg·mL^(-1))showed more obvious effect.Compared with the control group,SYI(0.4 mg·mL^(-1))reduced the blood pressure at 120 min after the administration.SYI(0.5 mg·mL^(-1))enhanced the solubilization of blood clots in vitro.Conclusion SYI can increase the blood flow,reduce the blood flow resistance and blood pressure of the carotid artery communis in normal rats,and displays thrombolytic effect in vitro.

关 键 词：注射用红花黄色素 红花黄色素A 血流量 血压 血流阻力 血栓溶解 

分 类 号：R285[医药卫生—中药学]