成人癌症恶病质的筛查评估与干预治疗——基于《成人癌症恶病质:ESMO临床实践指南》解读  

Screening Assessment and Therapy Intervention of Cancer Cachexia in Adult Patients--Based on the Interpretation of Cancer Cachexia in Adult Patients:ESMO Clinical Practice Guidelines

作　　者：王瑞 王小梅[1] 彭国庆 余欢 王思涵 夏瑾[1] WANG Rui;WANG Xiaomei;PENG Guoqing;YU Huan;WANG Sihan;XIA Jin(Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400060,China)

机构地区：[1]重庆医科大学附属第二医院肝胆外科,重庆市400060

出　　处：《中国全科医学》2023年第23期2823-2829,共7页Chinese General Practice

基　　金：重庆市科卫联合医学科研项目(2020FYYX248);重庆市技术创新与应用发展专项面上项目(cstc2019jscxmsxmX0117);重庆医科大学附属第二医院“宽仁英才”项目——宽仁三全护理创新研究中心团队。

摘　　要：癌症恶病质是与癌症相关的、多因素导致的、不可逆的、以进行性营养消耗为特点的临床综合征,降低了癌症患者生存预期和生活质量。2010年,欧洲姑息治疗研究协作组发布了《晚期癌症恶液质指南》,基于临床证据对晚期癌症患者恶液质进行分类和提供治疗建议,但该指南主要适用于可能出现难治性恶液质的晚期癌症患者。基于不断更新的研究证据,2021年4月欧洲肿瘤内科学会发布了《成人癌症恶病质:ESMO临床实践指南》,该指南关注所有可能发生恶病质的癌症患者,从恶病质的筛查、评估和多模式管理等内容提出建议,为临床癌症恶病质的管理提供了清晰的结构框架。本文对该指南进行解读,总结该指南要点,以期为我国临床癌症恶病质管理实践提供参考依据。Cancer cachexia is a cancer-related,multi-factorial,irreversible clinical syndrome characterized by progressive nutritional consumption,which greatly reduces the survival expectation and quality of life of cancer patient.In 2010,the European Palliative Care Research Collaborative published the Clinical Practice Guideline on Cancer Cachexia in Advanced Cancer Patients,which based on clinical evidence,providing recommendations about cachexia classification and treatment in patients with advanced cancer.However,the guideline is mainly applicable to patients with advanced cancer who may present with refractory cachexia.Based on the continuously updated evidence,the European Society of Medical Oncology released the Cancer Cachexia in Adult Patients:ESMO Clinical Practice Guideline,which provides a more clear structural framework for the management of cancer cachexia,focusing on all cancer patient who may develop into cachexia,making recommendations in terms of screening,evaluation and multimodal management of cachexia.This paper interprets and summarizes the key points of the guideline in order to provide a reference for clinical management of cancer cachexia in China.

关 键 词：肿瘤 癌症 恶病质 指南 筛查 治疗 管理 欧洲肿瘤内科学会 

分 类 号：R589.2[医药卫生—内分泌]