中医药治疗成人咳嗽变异性哮喘病的临床用药规律分析  

An analysis of medication rure of TCM on adult cough variant asthma

作　　者：潘乐乐 邹小娟[1] PAN Lele

机构地区：[1]湖北中医药大学,湖北武汉430065

出　　处：《中医临床研究》2023年第4期64-69,共6页Clinical Journal Of Chinese Medicine

摘　　要：目的:基于数据挖掘方法探讨现代中医药治疗咳嗽变异性哮喘(Cough Variant Asthma,CVA)的用药规律和组方特点。方法:计算机检索2000年-2021年中国知网、万方数据、维普数据库、中国生物医学文献数据库中关于中医药治疗CVA的研究,筛选符合纳入标准的文献,建立Excel规范化数据库;基于数据挖掘技术统计分析药物的性味归经、功效、主治,同时发现其关联规则和复杂系统聚类关系。结果:共纳入符合条件的文献97篇,涉及中药144味,累计药物使用频次1107次。用药频次较高的药物为杏仁、炙麻黄、生甘草、蝉蜕、地龙、紫菀、桔梗、僵蚕、五味子、防风。常用的药物类型为解表药、补虚药、止咳平喘药、化痰药、平肝息风药、清热药。关联规则分析结果显示药对关联规则有17对,三味中药配伍的关联规则有38条,四味中药配伍的关联规则24条,基本为解表药、化痰止咳平喘药和祛风解痉药物相配伍。聚类分析挖掘出5个核心组方,为款冬花、白前、桔梗、百部、紫菀、前胡、蝉蜕、地龙、陈皮、荆芥等的组合加减。结论:中医药治疗CVA以宣肺疏风、止咳化痰、祛风解痉为主,辨证加减予以理气、化湿、收涩、清热等。通过本次数据挖掘得出的用药和组方规律对临床中医药辨证治疗CVA具有一定的参考价值,可以为新方组合提供思路和借鉴。Objective:To explore the medication rule and prescription characteristics of modern TCM medicine on cough variant asthma based on data mining method.Methods:The studies on treating cough variant asthma in TCM from 2000 to 2021 were retrieved by computer in CNKI,Wanfang Data,VIP database and China Biomedical Literature Database.The literature met the criteria was strictly screened and included,and the standardized Excel database was established.Based on the data mining technology,the medicinal properties,medicinal taste,meridian tropism,and main efficacy of medicines in the included prescriptions were analyzed statistically,and the association rules and complex system clustering relationships were found.Results:A total of 97 studies met the criteria were included,involving 144 TCM medicines,and the cumulative medication frequency was 1107 times.The medicines with high used frequency were Xingren(Semen Armeniacae Amarum),Mahuang(Herba Ephedrae),Shenggancao(Radix Glycyrrhizae),Chantui(Periostracum Cicadae),Dilong(Pheretima),Ziyuan(Radix Asteris),Jiegeng(Radix Platycodonis),Jiangcan(Bombyx Batryticatus),Wuweizi(Fructus Schisandrae Chinensis),Fangfeng(Radix Saposhnikoviae).The commonly used types were antipyretic medicines,tonifying medicines,anticough and antiasthmatic medicines,antiphlegm medicines,soothe liver and wind medicines,and heat-clearing medicines.The analysis results showed that there were 17 paired medicines association rules,a total of 38 three-matched medicine association rules,and 24 four-matched medicine association rules,which were basically the compatibility of antipyretic medicines,antitustic phlegm medicines,antiasthmatic medicines and antispasmodic medicines.Five core components were excavated by the cluster analysis,which were based on the combinations of Kuandonghua(Flos Farfarae),Baiqian(Rhizoma Cynanchi Stauntonii),Jiegeng,Baizhu(Rhizoma Atractylodis Macrocephalae),Ziwan,Qianhu(Radix Peucedani),Chantui,Dilong,Chenpi(Pericarpium Citri Reticulatae)and Jingjie(Herba Schizonepetae).Conclusions:I

关 键 词：咳嗽变异性哮喘 中药 频次 数据挖掘 用药规律 

分 类 号：R256.12[医药卫生—中医内科学]