角质细胞生长因子-2与新生儿相关肺部疾病的研究进展  

Research progress of keratinocyte growth factor-2 and neonatal-related lung diseases

作　　者：侯琳(综述) 舒桂华(审校)[2] HOU Lin;SHU Guihua(Dalian Medical University,Dalian,Liaoning 116044,China;Department of Neonatology,Northern Jiangsu People's Hospital,Yangzhou,Jiangsu 225001,China)

机构地区：[1]大连医科大学,辽宁大连116044 [2]江苏省苏北人民医院新生儿科,江苏扬州225001

出　　处：《检验医学与临床》2023年第9期1302-1306,共5页Laboratory Medicine and Clinic

摘　　要：角质细胞生长因子-2(KGF-2)是一类来源于间充质细胞的生长因子,具有多功能生物学作用,特别其作为一种肺组织保护因子,可调控肺泡上皮细胞增殖、分化及迁移,促进受损肺组织修复和抑制肺泡纤维化。KGF-2缺失或基因突变与新生儿相关肺部疾病的发生、发展密切相关,且有增加儿童期甚至成年后发生慢性肺部疾病的风险。本文就KGF-2结构、生物学功能,以及其与新生儿相关肺部疾病的关系做一综述,旨在为开拓新生儿呼吸系统疾病新的诊治策略提供理论参考依据。Keratinocyte growth factor-2(KGF-2),which has multifunctional biological effects,particular-ly as a lung tissue protective factor,is a kind of growth factor derived from mesenchymal cells,and it can regu-late the proliferation,differentiation and migration of alveolar epithelial cells,promote the repair of damaged lung tissue and inhibit alveolar fibrosis.KGF-2 deletion or gene mutation is closely related to the occurrence and development of neonatal lung diseases,it has an increased risk of chronic lung diseases in childhood and e-ven adulthood.This article reviews the structure and biological function of KGF-2 and its relationship with neonatal related lung diseases,aiming to provide theoretical reference for the development of new diagnosis and treatment strategies for neonatal respiratory diseases.

关 键 词：角质细胞生长因子-2 新生儿 肺部疾病 

分 类 号：R722.1[医药卫生—儿科]