高氧致细胞衰老在支气管肺发育不良中的作用  

The role of hyperoxia-induced cellular senescence in bronchopulmonary dysplasia

作　　者：张雅茹(综述) 邓欢 由凯(审校)[1] Zhang Yaru;Deng Huan;You Kai(Department of Pediatrics,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院儿内科,沈阳110004

出　　处：《国际儿科学杂志》2023年第3期169-172,共4页International Journal of Pediatrics

基　　金：国家自然科学基金青年基金(81501292);中国博士后基金面上项目(2017M611285);辽宁省基础研究计划项目(2022JH2/101500053)。

摘　　要：支气管肺发育不良(bronchopulmonary dysplasia,BPD)是一种可造成早产儿呼吸衰竭及死亡的慢性呼吸系统疾病,高氧暴露是其发生的主要危险因素。细胞衰老描述了一种细胞周期阻滞的状态,近年来有研究证实高氧暴露可以引起细胞衰老。细胞衰老在肺上皮、肺间质、肺血管以及气道发育过程中起着至关重要的作用,且这些组织的异常发育与BPD的发生相关。因此,该文以细胞衰老和BPD为切入点进行综述,探讨高氧致细胞衰老在BPD发生发展中的作用机制以及目前应用于临床的抗衰老药物,以期为BPD的防治提供新方向。Bronchopulmonary dysplasia(BPD)is a chronic respiratory system disease that causes respiratory failure and death in premature infants,and hyperoxic exposure is the main risk factor for its occurrence.Cellular senescence describes a state of cell cycle blockade,and in recent years studies have confirmed that exposure to hyperoxia can cause cellular senescence.Cellular senescence plays a crucial role in the development of the lung epithelium,lung interstitium,pulmonary vasculature,and airways,and abnormal development of these tissues is associated with the development of BPD.Therefore,this paper takes cellular senescence and BPD as the starting point to review the mechanism of hyperoxia-induced cellular senescence in the occurrence and development of BPD and the anti-aging drugs currently applied in clinical practice,in order to provide a new direction for the prevention and treatment of BPD.

关 键 词：细胞衰老 支气管肺发育不良 高氧 治疗 

分 类 号：R722.6[医药卫生—儿科]