增生性瘢痕的发病机制及防治研究新进展  

New research advances in hypertrophic scar formation, prevention and treatment

作　　者：陈玲[1] 晏卉 周蓓 徐泳芳 李俊[1] Chen Ling;Yan Hui;Zhou Bei;Xu Yongfang;Li Jun(Department of Plastic Surgery,Women′s Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)整形外科,南京210004

出　　处：《中华预防医学杂志》2023年第4期597-606,498,共11页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金项目(82002041);南京市卫生科技发展专项资金项目(YKK21164)。

摘　　要：瘢痕是人体创伤修复过程中的必然产物,成纤维细胞(fibroblasts,Fb)是主要的效应细胞。其生物学行为很大程度上决定了修复结局,若Fb过量增殖,细胞外基质合成增加或分解不足即可导致增生性瘢痕。目前,增生性瘢痕的发病机制仍不清楚,一般认为与Fb的功能异常,调控信号通路关系密切。而增生性瘢痕Fb的生物学行为受较多因素影响,主要包括细胞因子、细胞外基质及Fb自身变化等。此外,微RNA、竞争性内源性RNA、长链非编码RNA、多肽、组蛋白修饰等通过影响Fb生物学功能,亦参与瘢痕的增生。在瘢痕防治方面,切入点多集中于Fb及其胶原的分泌。本文阐述了近年来瘢痕相关的临床及基础研究,以期为预防及治疗瘢痕增生提供更全面的认知与视角。Scarring,naturally induced by fibroblasts(Fb)during wound healing,is an essential process in response to repair damaged tissue.Excessive Fb proliferation which produces the excessive collagen deposition,including increased extracellular matrix synthesis or insufficient decomposition,typically contributes to hypertrophic scar(HS)formation.Although exact mechanisms of HS are not yet fully understood,it is generally believed that dysfunction of Fb and regulation of signal pathways play an important role in HS formation.Biologically,Fb function is affected by various factors such as cytokines,extracellular matrix and itself.In addition,modifications of miRNA,ceRNA,lncRNA,peptides and histones participate in HS formation by affecting the biological function of Fb.Despite the clinical importance,very few therapeutic modalities are available to prevent HS.To achieve this,a deeper characterization of Fb is required to identify mechanisms of HS.To the aspect of HS prevention and treatment,we review recent findings,concentrating on Fb function and collagen secretion.The objective of this article is to frame the current understanding,gain the deeper insights into Fb function,and provide the more comprehensive cognition and perspective for prevention and treatment of HS.

关 键 词：增生性瘢痕 成纤维细胞 机制 防治 

分 类 号：R622[医药卫生—整形外科]