颈复康颗粒联合神经妥乐平治疗神经根型颈椎病的临床研究  

Clinical study on Jingfukang Granules combined with neurotropin in treatment of cervical spondylotic radiculopathy

作　　者：付学敬 朱琳[1] 韩崇涛[2] FU Xue-jing;ZHU Lin;HAN Chong-tao(Department of Orthopedics and Traumatology,the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Department of Orthopedics,the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第三附属医院骨伤科,河南郑州450000 [2]河南中医药大学第三附属医院骨病科,河南郑州450000

出　　处：《现代药物与临床》2023年第3期612-615,共4页Drugs & Clinic

基　　金：河南省中医药科学研究专项(2022ZY2037)。

摘　　要：目的探讨颈复康颗粒联合神经妥乐平治疗神经根型颈椎病的临床疗效。方法选择2020年6月—2022年6月河南中医药大学第三附属医院收治的60例神经根型颈椎病患者,随机分为对照组(30例)和治疗组(30例)。对照组口服神经妥乐平片,4片/次,2次/d。在对照组的基础上,治疗组口服颈复康颗粒,1袋/次,2次/d。两组服用药物14 d。观察两组患者临床疗效,比较治疗前后两组患者症状改善时间,颈椎功能障碍指数评分(NDI)和视觉模拟疼痛评分(VAS),及血清炎性因子白细胞介素-1β(IL-1β)、丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)和皮质醇(Cor)水平。结果治疗后,治疗组总有效率为96.67%,显著高于对照组(73.33%,P<0.05)。治疗后,治疗组症状改善时间均明显早于对照组(P<0.05)。治疗后,两组患者NDI评分和VAS评分均明显降低(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组血清炎性因子IL-1β、MDA和TNF-α水平明显降低,而Cor水平明显升高(P<0.05),且治疗组IL-1β、MDA、TNF-α和Cor水平明显好于对照组(P<0.05)。结论神经妥乐平联合颈复康颗粒治疗神经根型颈椎病效果确切,可减轻患者疼痛,有效改善患者炎性因子水平,颈椎功能恢复良好。Objective To investigate the curative effect of Jingfukang Granules combined with neurotropin in treatment of cervical spondylotic radiculopathy.Methods Patients(60 cases)with cervical spondylotic radiculopathy in the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from June 2020 to June 2022 were randomly divided into control(30 cases)and treatment(30 cases)group.Patients in the control group was po administered with Neurotropin Tablets,4 tablets/time,twice daily.Patients in the treatment group were po administered with Jingfukang Granules on the basis of the control group,1 bag/time,twice daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluation was evaluated,and the improvement time of symptom,NDI score and VAS score,the levels of serum factor IL-1β,MDA,TNF-α,and Cor in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 96.67%,which was significantly higher than that of the control group(73.33%,P<0.05).After treatment,the improvement time of symptom in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the scores of NDI and VAS in two groups were significantly decreased,and which in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of serum inflammatory factors IL-1β,MDA,and TNF-αin two groups were significantly decreased,while the level of Cor was significantly increased(P<0.05),and the levels of IL-1β,MDA,TNF-α,and Cor in the treatment group were significantly better than those in the control group(P<0.05).Conclusion The effect of neurotropin combined with Jingfukang Granules in treatment of cervical spondylotic radiculopathy is accurate,which can relieve the pain of patients,effectively improve the level of inflammatory factors,and the function of cervical vertebra recovers well.

关 键 词：颈复康颗粒 神经妥乐平片 神经根型颈椎病 颈椎功能障碍指数评分 丙二醛 皮质醇 

分 类 号：R971[医药卫生—药品]