康复新液联合注射用矛头蝮蛇血凝酶治疗胃溃疡出血的临床研究  

Clinical study on Kangfuxin Liquid combined with Hemocoagulase Bothrops Atrox for injection in treatment of gastric ulcer bleeding

作　　者：周祥武 陈贵进 丁洪亮 卓锦春 刘序 ZHOU Xiang-wu;CHEN Gui-jin;DING Hong-liang;ZHUO Jin-chun;LIU Xu(Department of General Surgery,General Hospital of the Southern Theater Command of the Chinese People’s Liberation Army,Guangzhou 510010,China)

机构地区：[1]中国人民解放军南部战区总医院普外科,广东广州510010

出　　处：《现代药物与临床》2023年第3期660-664,共5页Drugs & Clinic

摘　　要：目的 探讨康复新液联合注射用矛头蝮蛇血凝酶治疗胃溃疡出血的临床疗效。方法 选取2020年12月—2021年12月在中国人民解放军南部战区总医院治疗的86例胃溃疡出血患者,按照治疗方法不同将所有患者分为对照组和治疗组,每组各43例。对照组患者静脉注射注射用矛头蝮蛇血凝酶,将1单位注射用矛头蝮蛇血凝酶溶于10 m L 0.9%氯化钠溶液中,2次/d。治疗组在对照组基础上口服康复新液,10 mL/次,3次/d。两组患者连续治疗3 d。观察两组的临床疗效,比较两组的止血时间、再出血发生率、凝血功能、血清学指标。结果 治疗后,治疗组总有效率为95.35%,显著高于对照组的总有效率81.39%(P<0.05)。治疗后,治疗组止血时间明显短于对照组,再出血发生率低于对照组(P<0.05)。治疗后,两组患者血浆活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)均明显短于治疗前,纤维蛋白原(FIB)水平明显高于治疗前(P<0.05);治疗后,治疗组APTT、PT明显短于对照组,FIB水平明显高于对照组(P<0.05)。治疗后,两组血管内皮生长因子、表皮生长因子受体水平均明显高于治疗前(P<0.05);治疗后,治疗组血管内皮生长因子、表皮生长因子受体水平明显高于对照组(P<0.05)。结论 康复新液联合注射用矛头蝮蛇血凝酶治疗胃溃疡出血疗效确切,可缩短胃溃疡出血患者止血时间,改善凝血功能。Objective To investigate the therapeutic effect of Kangfuxin Liquid combined with Hemocoagulase Bothrops Atrox for injection in treatment of gastric ulcer bleeding. Methods Patients(86 cases) with gastric ulcer bleeding in General Hospital of the Southern Theater Command of the Chinese People’s Liberation Army from December 2020 to December 2021 were divided into control and treatment groups according to different treatment methods, and each group had 43 cases. Patients in the control group were iv administered with Hemocoagulase Bothrops Atrox for injection, 1 unit added into 0.9% sodium chloride solution 10 mL, twice daily.Patients in the treatment group were po administered with Kangfuxin Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 3 d. After treatment, the clinical efficacies were evaluated, and hemostatic time, rebleeding rate, coagulation function, and serological indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.35%, which was significantly higher than that(81.39%) of the control group(P < 0.05). After treatment,the hemostatic time in the treatment group was significantly shorter than that in the control group, and rebleeding rate was lower than that in the control group(P < 0.05). After treatment, APTT and PT in two groups were significantly shorter than those before treatment,but FIB levels were significantly higher than those before treatment(P < 0.05). After treatment, APTT and PT in the treatment group were significantly shorter than those in the control group, but FIB levels were significantly higher than those in the control group(P <0.05). After treatment, the levels of vascular endothelial growth factor and epidermal growth factor receptor in two groups were significantly higher than those before treatment(P < 0.05). After treatment, the levels of vascular endothelial growth factor and epidermal growth factor receptor in the treatment group were significantly

关 键 词：康复新液 注射用矛头蝮蛇血凝酶 胃溃疡出血 止血时间 再出血发生率 凝血酶原时间 血管内皮生长因子 表皮生长因子受体 

分 类 号：R975[医药卫生—药品]