米非司酮联合甲氨蝶呤治疗异位妊娠的临床效果  

Clinical effect of mifepristone combined with methotrexate in the treatment of ectopic pregnancy

作　　者：杨治凤 李江鹏[2] 李莉 YANG Zhifeng;LI Jiangpeng;LI Li(Gynecology and Obstetrics Department,Gaoling District Maternal and Child Health Hospital,Xi'an 710200;Gynecology and Obstetrics Department,Xi'an Fourth Hospital,Xi'an 710004;Gynecology and Obstetrics Department,Gaoling District Hospital,Xi'an 710200,China)

机构地区：[1]高陵区妇幼保健院妇产科,陕西西安710200 [2]西安市第四医院妇产科,陕西西安710004 [3]高陵区医院妇产科,陕西西安710200

出　　处：《临床医学研究与实践》2023年第14期87-90,共4页Clinical Research and Practice

摘　　要：目的研究米非司酮联合甲氨蝶呤治疗异位妊娠(EP)的效果。方法选取本院2017年1月至2021年1月收治的100例EP患者为研究对象,利用硬币分组法将其分为对照组和观察组,各50例。对照组给予甲氨蝶呤治疗,观察组给予米非司酮联合甲氨蝶呤治疗。比较两组的血β-人绒毛膜促性腺激素(β-HCG)、肌酸激酶(CK)、孕酮(P)、血管内皮生长因子(VEGF)水平、炎症因子、性生活质量、疾病恢复情况及不良反应发生情况。结果用药后,观察组的β-HCG、CK、P及VEGF水平低于对照组(P<0.05)。用药后,观察组的白介素-2(IL-2)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及干扰素-γ(IFN-γ)水平低于对照组(P<0.05)。用药后,观察组的性唤起、性高潮、性满意度及阴道湿润评分均高于对照组(P<0.05)。观察组的包块消失时间、阴道出血消失时间、腹痛消失时间、月经复潮时间及住院时间短于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论米非司酮联合甲氨蝶呤治疗EP患者可缓解其临床症状,调节炎症因子水平,改善性生活质量,缩短疾病恢复时间。Objective To study the effect of mifepristone combined with methotrexate in the treatment of ectopic pregnancy(EP).Methods A total of 100 EP patients admitted in our hospital from January 2017 to January 2021 were selected as the research objects.The patients were divided into control group and observation group by coin grouping method,with 50 cases in each group.The control group was treated with methotrexate,and the observation group was treated with mifepristone combined with methotrexate.The levels ofβ-human chorionic gonadotropin(β-HCG),creatine kinase(CK),progesterone(P),vascular endothelial growth factor(VEGF),inflammatory factors,quality of sexual life,disease recovery and adverse reactions were compared between the two groups.Results After medication,the levels ofβ-HCG,CK,P and VEGF in the observation group were lower than those in the control group(P<0.05).After medication,the levels of interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and interferon-γ(IFN-γ)in the observation group were lower than those in the control group(P<0.05).After medication,the scores of sexual arousal,orgasm,sexual satisfaction and vaginal wetness in the observation group were higher than those in the control group(P<0.05).The mass disappearance time,vaginal bleeding disappearance time,abdominal pain disappearance time,menstrual recovery time and hospital stay in the observation group were shorter than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Mifepristone combined with methotrexate in the treatment of EP patients can alleviate clinical symptoms,regulate the level of inflammatory factors,improve the quality of sexual life,and shorten the recovery time of the disease.

关 键 词：米非司酮 甲氨蝶呤 异位妊娠 

分 类 号：R714.22[医药卫生—妇产科学]