血管生成素样蛋白调控缺血性视网膜病变血管生成及血管通透性的作用研究  

Study on the role of angiopoietin-like protein on angiogenesis and vascular permeability in ischemic retinopathy

作　　者：闫洁 李晶明 秦莉 李武军 YAN Jie;LI Jingming;QIN Li;LI Wujun(Ophthalmology Department,Traditional Chinese Medicine Hospital of Yulin,Yulin 719000,China)

机构地区：[1]榆林市中医医院眼科,陕西榆林719000

出　　处：《临床医学研究与实践》2023年第14期191-194,共4页Clinical Research and Practice

基　　金：榆林市科协青年人才托举计划项目(No.20210310)。

摘　　要：血管生成素样蛋白(ANGPTLs)是一类结构类似于血管生成素的分泌型糖蛋白,其家族包括8个成员。ANGPTLs与血管生成素同样具备调节血管生成及血管通透性的能力,却不能与血管生成素特异性受体(Tie1或Tie2)结合,提示ANGPTLs可能通过不同的机制及通路在机体中发挥作用。缺血性视网膜病变(IR)是一组严重影响视力健康的疾病,由不成熟视网膜脉管系统或成熟的视网膜血管损伤造成视网膜缺血,进而导致视网膜血管渗漏或新生血管形成而引起,近年研究发现ANGPTL家族部分成员与IR新生血管形成及血管渗漏有关,提出将其中某些成员作为IR潜在治疗靶标。本综述的目的是描述ANGPTLs在IR中对血管生成及血管通透性的作用及参与其中的分子机制,为相关因子作为IR的潜在治疗靶标提供有用信息。Angiopoietin-like proteins(ANGPTLs)are a class of secreted glycoproteins with a structure similar to angiopoietin,and the family includes 8 members.ANGPTLs have the same ability to regulate angiogenesis and vascular permeability as angiopoietin,but can not bind to angiopoietin-specific receptors(Tie1 or Tie2),suggesting that ANGPTLs may play role in the body through different mechanisms and pathways.Ischemic retinopathy(IR)is a group of diseases that seriously affect visual health,it is due to retinal ischemia caused by immature retinal vascular system or injury of mature retinal vascular,which leads to retinal vascular leakage or neovascularization.Recent studies have found that some members of the ANGPTL family are related to IR neovascularization and vascular leakage,and some of them are proposed as potential therapeutic targets for IR.The purpose of this review is to describe the role of ANGPTLs in angiogenesis and vascular permeability in IR and the molecular mechanisms involved,and to provide useful information for related factors as potential therapeutic targets for IR.

关 键 词：血管生成素样蛋白 缺血性视网膜病变 血管生成 血管通透性 血管内皮细胞生长因子 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]