对甲苯磺酸三氟乙酯合成的优化  

Optimization of Synthesis of Trifluoroethyl p-Toluenesulfonate

作　　者：姚卫国 胡凯瑞 高鹏飞 王心可 宫聿泽 郑刚 刘勇营 YAO Wei-guo;HU Kai-rui;GAO Peng-fei;WANG Xin-ke;GONG Yu-ze;ZHENG Gang;LIU Yong-ying(Sinochem Lantian Fluoro Materials Co.,Ltd.,Shaoxing,Zhejiang 312369,China;Zhejiang Research Institute of Chemical Industry Co.,Ltd.,Hangzhou,Zhejiang 310023,China)

机构地区：[1]中化蓝天氟材料有限公司,浙江绍兴312369 [2]浙江省化工研究院有限公司,浙江杭州310023

出　　处：《浙江化工》2023年第4期1-3,8,共4页Zhejiang Chemical Industry

摘　　要：为了提高对甲苯磺酸三氟乙酯的收率,本研究主要对其合成工艺进行优化,通过对甲苯磺酰氯和三氟乙醇的投料比、液碱滴加速率、静置时间的优化,有效提高酯的收率,最后考察试验的稳定性。得到以下结果:三氟乙醇和对甲苯磺酰氯的质量比为0.56,液碱的滴加速率为0.77 kg/min,最优静置时间为2 h,产品收率大于95%,水分含量小于0.2%。In order to improve the yield of trifluoroethyl toluenesulfonate,the synthesis process was mainly optimized,and the feeding ratio,liquid alkali drop acceleration rate and standing time of p-toluenesulfonyl chloride and trifluoroethanol were optimized to effectively improve the ester yield,and finally the stability of the test was investigated.The following results were obtained:the mass ratio of trifluoroethanol and p-toluenesulfonyl chloride was 0.56,the drop acceleration rate of liquid alkali was 0.77 kg/min,the optimal standing time was 2 h,the product yield was greater than 95%,and the moisture content was less than 0.2%.

关 键 词：对甲苯磺酸三氟乙酯 优化 投料比 滴加速率 稳定性 

分 类 号：TQ225.24[化学工程—有机化工]