基于数据挖掘探讨中医药治疗病毒性心肌炎用药规律  

Study on the Medication Law of TCM in the Treatment of Viral Myocarditis Based on Data Mining

作　　者：牛越 温志浩[2,3] NIU Yue;WEN Zhihao(Guangxi University of Chinese Medicine,Nanning 530200,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Branch of China Center for Clinical Medical Research of Cardiovascular Diseases of Traditional Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学,广西南宁530200 [2]广西中医药大学第一附属医院,广西南宁530200 [3]中国中医心血管病临床医学研究中心广西分中心,广西南宁530023

出　　处：《中国中医药图书情报杂志》2023年第3期58-63,共6页Chinese Journal of Library and Information Science for Traditional Chinese Medicine

基　　金：国家自然科学基金地区基金(81660778、82160887);国家自然科学基金青年基金(81403381);广西壮族自治区中药管理局第三批中医壮瑶医治疗优势病种研究项目(GZBZ21-2);广西中医药适宜技术开发与推广项目(GZSY21-17)。

摘　　要：目的基于数据挖掘分析中医药治疗病毒性心肌炎的用药规律,为临床治疗病毒性心肌炎提供参考。方法计算机检索中国知识资源总库(CNKI)、中文科技期刊数据库(维普网)、万方数据知识服务平台(万方数据)2000年1月1日-2022年1月1日中医药治疗病毒性心肌炎相关的文献,遵循纳入和排除标准提取处方信息。运用古今医案云平台2.3.5,进行药物频次、药物属性、关联分析、复杂网络分析及聚类分析。结果最终纳入处方169首,涉及中药288味,高频药物为丹参、麦冬、黄芪、五味子、炙甘草、当归、金银花、连翘、桂枝、苦参等;药性以微寒、温、平居多;药味以甘、苦、辛居多;归经以心、肺、胃为主;药物以补虚药、清热解毒药、活血化瘀药居多;关联分析得到14个常用药对;复杂网络分析发现其核心药物为丹参、麦冬、五味子、黄芪、炙甘草、金银花、当归等;聚类分析得到治疗病毒性心肌炎中药可分为3类。结论病毒性心肌炎基本病机为本虚标实,临床常用补虚药、清热解毒药、活血化瘀药,生脉散、银翘散、炙甘草汤等为常用基础方,可为临床治疗病毒性心肌炎提供参考依据。Objective To analyze the medication law of TCM in the treatment of viral myocarditis based on data mining;To provide clinical data support and reference for the treatment of viral myocarditis.Methods The literature about the TCM treatment of viral myocarditis was retrieved from CNKI,VIP,Wanfang Data and CBM from 1st,Jan.2000 to 1st,Jan.2022,and the prescription information was extracted according to the inclusion and exclusion criteria.The ancient and modern medical case cloud platform(v2.3.5)was used to carry out drug frequency,drug attribute,association analysis,complex network analysis and clustering analysis.Results Totally 169 prescriptions were included,involving 288 kinds of Chinese materia medica.The high-frequency drugs were Salviea Miltiorrhizae Radix et Rhizoma,Ophiopogonis Radix,Astragali Radix,Schisandrae Chinensis Fructus,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Angelicae Sinensis Radix,Lonicerae Japonicae Flos,Forsythiae Fructus,Cinnamomi Ramulus,and Sophorae Flavescentis Radix;the drug properties were mostly mild cold,warm and mild;the medicine tastes were mainly sweet,bitter and pungent;the main meridians were heart,lung and stomach;most of the drugs were tonic drugs,heat-clearing and detoxifying drugs and drugs for promoting blood circulation and removing blood stasis;14 common medicinal pairs were obtained by correlation analysis,complex network analysis found that the core drugs were Salviea Miltiorrhizae Radix et Rhizoma,Ophiopogonis Radix,Astragali Radix,Schisandrae Chinensis Fructus,Glycyrrhizae Radix et Rhizoma Praeparata cum Melle,Angelicae Sinensis Radix,Lonicerae Japonicae Flos and so on.According to clustering analysis,TCM for the treatment of viral myocarditis can be divided into three categories.Conclusion The basic pathogenesis of viral myocarditis is based on deficiency in root and excess in symptoms.Drugs for tonifying deficiency,clearing heat and detoxification,promoting blood circulation and removing blood stasis are commonly used in clinic.Shengmai Powder,Yinqiao Powd

关 键 词：病毒性心肌炎 数据挖掘 中医药 用药规律 

分 类 号：R2-05[医药卫生—中医学] R259.422