济生肾气丸加减联合改良督灸治疗脾肾阳虚型糖尿病肾病临床观察  

Clinical Observation of Modified Life-Saving Kidney Qi Pills Combined with Improved Moxibustion at GV in the Treatment of Diabetic Nephropathy with Spleen-Kidney Yang Deficiency Syndrome

作　　者：左飞龙 时吉来[1] 张珊珊[1] ZUO Fei-long;SHI Ji-lai;ZHANG Shan-shan(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong,China,250014)

机构地区：[1]山东中医药大学附属医院,山东济南250014

出　　处：《河南中医》2023年第5期750-753,共4页Henan Traditional Chinese Medicine

基　　金：山东省中医药管理局项目(20190958)。

摘　　要：目的:观察济生肾气丸加减联合改良督灸治疗脾肾阳虚型糖尿病肾病的临床疗效。方法:经山东中医药大学附属医院伦理会审批后,选择2020年10月至2021年11月山东中医药大学附属医院内分泌科收治的60例糖尿病肾病患者作为研究对象,按随机数字表法分为观察组和对照组,每组30例。两组患者均给予基础治疗,观察组另给予济生肾气丸加减联合改良督灸治疗。观察两组患者治疗前后中医证候积分、肾功能指标[血肌酐(serum creatinine,Scr)、血尿素氮(blood urea nitrogen,BUN)及24 h尿蛋白定量]变化情况及临床疗效、不良反应发生情况。结果:观察组有效率为86.67%,对照组有效率为63.33%,观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后神疲乏力、腰膝酸软、肢体浮肿、尿浊、五更泄泻等中医证候评分均低于对照组,差异有统计学意义(P<0.05);观察组治疗后SCr、BUN、24 h尿蛋白定量水平低于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:济生肾气丸加减联合改良督灸治疗脾肾阳虚型糖尿病肾病可提高临床疗效,改善患者中医证候、肾功能。Objective:To observe the clinical efficacy of Modified Life-Saving Kidney Qi Pills combined with improved moxibustion at GV on diabetic nephropathy(DN)with spleen-kidney yang deficiency syndrome.Methods:After approval by The Ethics Committee of Affiliated Hospital of Shandong University of Traditional Chinese Medicine,60 DN patients admitted to The Endocrinology Department of Affiliated Hospital of Shandong University of Traditional Chinese Medicine from October 2020 to November 2021 were selected as the research subjects.They were randomly divided into the observation group and the control group,with 30 cases in each group.Both groups were first given basic treatment,then the observation group was additionally treated with Modified Life-Saving Kidney Qi Pills combined with improved moxibustion at GV.The TCM syndrome scores,renal function indicators[including serum creatinine(Scr),blood urea nitrogen(BUN),and 24-hour urine protein quantification]before and after treatment in two groups,as well as the clinical efficacy and occurrence of adverse reactions were observed.Results:The effective rate of the observation group was 86.67%,while that of the control group was 63.33%.The effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);After treatment,the scores of TCM syndromes such as fatigue,soreness in the waist and knees,limb edema,turbid urine,and diarrhea in the observation group were lower than those in the control group,and all the differences were statistically significant(P<0.05);the SCr,BUN,and 24-hour urine protein quantitative levels in the observation group were lower than those in the control group,and all the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion:Modified Life-Saving Kidney Qi Pills combined with improved moxibustion at GV can improve the clinical efficacy of DN with spleen-kidney

关 键 词：糖尿病肾病 脾肾阳虚证 济生肾气丸 督灸 

分 类 号：R259.872[医药卫生—中西医结合]