针刺联合复方苁蓉益智胶囊治疗痰浊阻窍型血管性痴呆临床观察  

Clinical Observation of Acupuncture Combined with Compound Cistanche Yizhi Capsules in the Treatment of Vascular Dementia with Phlegm Turbidity Obstructing Orifices Syndrome

作　　者：王欢[1] 吕长虹 郭晓娜 李惠军[1] 苏晓光 WANG Huan;LYU Chang-hong;GUO Xiao-na;LI Hui-jun;SU Xiao-guang(No.984 Hospital of PLA Joint Logistic Support Force,Beijing,China,100094)

机构地区：[1]中国人民解放军联勤保障部队第九八四医院,北京100094

出　　处：《河南中医》2023年第5期772-776,共5页Henan Traditional Chinese Medicine

基　　金：北京市科学研究重点研发计划项目(Z202160-26)。

摘　　要：目的:观察针刺联合复方苁蓉益智胶囊治疗痰浊阻窍型血管性痴呆的临床疗效。方法:选取2020年1月至2021年12月中国人民解放军联勤保障部队第九八四医院收治的痰浊阻窍型血管性痴呆患者120例,采用随机数字表法分为观察组和对照组,每组60例。对照组给予复方苁蓉益智胶囊治疗,观察组在对照组治疗的基础上加用针刺治疗。观察两组患者治疗前后精神状态量表(mini-mental state examination,MMSE)、日常活动能力量表(activities of daily living,ADL)、长谷川痴呆量表(hasegawa dementia scale,HDS)、颅内动脉收缩期峰值血流速度(peak systolic blood flow velocity,SPV)、舒张期末血流速度(end diastolic blood flow velocity,EDV)、平均血流速度(mean velocity,Vm)、血管阻力指数(resistance index,RI)、血流变学指标变化情况及临床疗效、不良反应发生情况。结果:观察组有效率为96.67%,对照组有效率为83.33%,观察组有效率高于对照组,差异有统计学意义(P<0.05);两组患者治疗后MMSE评分、HDS评分、ADL评分高于治疗前,中医证候积分低于治疗前,且观察组治疗后MMSE评分、HDS评分、ADL评分高于对照组,中医证候积分低于对照组,差异有统计学意义(P<0.05);两组患者治疗后颅内动脉SPV、EDV、Vm高于治疗前,RI低于治疗前,且观察组治疗后颅内动脉SPV、EDV、Vm高于对照组,RI低于对照组,差异有统计学意义(P<0.05);观察组治疗后全血高切黏度、全血低切黏度、血浆黏度低于对照组,差异有统计学意义(P<0.05);两组患者治疗期间未发现明显不良反应。结论:复方苁蓉益智胶囊联合针刺治疗痰浊阻窍型血管性痴呆,能改善患者精神状态、活动能力、痴呆症状、颅内动脉血流动力学参数及血液流变学指标。Objective:To observe the clinical efficacy of acupuncture combined with Compound Cistanche Yizhi Capsules on vascular dementia(VD)with phlegm turbidity obstructing orifices syndrome.Methods:A total of 120 patients with phlegm turbidity obstructing orifices syndrome admitted to No.984 Hospital of PLA Joint Logistic Support Force from January 2020 to December 2021 were selected and randomly divided into the observation group and the control group,with 60 cases in each group.The control group was treated with Compound Cistanche Yizhi Capsules,while the observation group was treated with acupuncture on the basis of the control group.The changes of mini-mental state examination(MMSE),activities of daily living(ADL),hasegawa dementia scale(HDS),peak systolic blood flow velocity(SPV),end diastolic blood flow velocity(EDV)Mean velocity(Vm),vascular resistance index(RI),blood rheology indicators,clinical efficacy and adverse reactions in the two groups before and after treatment were observed.Results:The effective rate of the observation group was 96.67%,while that of the control group was 83.33%.The effective rate of the observation group was higher than that of the control group,with a statistically significant difference(P<0.05);After treatment,the MMSE score,HDS score,and ADL score of the two groups were higher than those of the same group before treatment,while the TCM syndrome score was lower than that before treatment.Moreover,the MMSE score,HDS score,and ADL score of the observation group were higher than those of the control group,while the TCM syndrome score was lower than that of the control group,with statistically significant differences(P<0.05);The intracranial artery SPV,EDV,and Vm of the two groups were higher than those of the same group before treatment,while the RI was lower than that before treatment.Moreover,the observation group's intracranial artery SPV,EDV,and Vm were higher than those of the control group,while the RI was lower than that of the control group,with statistically significant differen

关 键 词：血管性痴呆 痰浊阻窍证 复方苁蓉益智胶囊 针刺疗法 

分 类 号：R259.491.3[医药卫生—中西医结合]