促渗剂对后交联祖师麻凝胶贴膏体外经皮渗透影响的研究  

Effect of Penetration Enhancers on Transdermal Penetration of Post-crosslinking Daphnes Giraldii Cortex Gel Plaster In Effect of Penetration Enhancers on Transdermal Penetration of Post-crosslinking Daphnes Giraldii Cortex Gel Plaster In Vitro

作　　者：徐镱文 李真真 王继龙 刘晓霞[1] 万玲娟 冉鑫 魏舒畅[1] XU Yiwen;LI Zhenzhen;WANG Jilong;LIU Xiaoxia;WAN Lingjuan;RAN Xin;WEI Shuchang(Gansu University of Chinese Medicine,Lanzhou 730000,China;Research Center of Traditional Chinese Medicine Pharmaceutical Technology and Engineering of Gansu Province,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中药制药工艺工程研究中心,兰州730000

出　　处：《中国现代应用药学》2023年第7期903-908,共6页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的考察不同促渗剂对后交联祖师麻凝胶贴膏中药效成分祖师麻甲素体外经皮渗透特性的影响,筛选出其最佳的透皮促渗剂。方法采用Franz扩散池法,以离体小鼠皮肤和Strat-M^(TM)膜为渗透屏障进行体外透皮试验,采用单因素及正交试验法,以祖师麻甲素72 h内单位面积的累积透过量为评价指标,考察冰片、薄荷脑、樟脑对祖师麻甲素的促渗效果。结果以离体小鼠皮肤和Strat-M^(TM)人工膜为透皮屏障时,祖师麻甲素72 h内单位面积的累积透过量分别为33.85,15.96μg·cm^(-2),稳态透皮速率分别为4.4512,2.3945μg·cm^(-2)·h^(-1),增渗倍数分别可达4.2550,1.7464。结论后交联祖师麻凝胶贴膏以1%薄荷脑、1%冰片、2%樟脑联用时促渗效果最佳。OBJECTIVE To investigate the effect of different penetration enhancers on the external transdermal absorption characteristics of the pharmacodynamic components of daphnetin in post-crosslinking Daphnes Giraldii Cortex gel plaster and screen out the best penetration enhancers.METHODS In vitro transdermal test was carried out with mouse skin and Strat-M^(TM)membrane as the penetration barrier by Franz diffusion cell method.Using the cumulative penetration rate per unit area of daphnetin within 72 h as the evaluation index,by single factor experiment and orthogonal experiment to investigate the promoting effect of borneol,menthol and camphor on the daphnetin.RESULTS When in vitro mouse skin and Strat-M^(TM)membrane were used as transdermal barrier,the cumulative transdermal flux per unit area was 33.85,15.96μg·cm^(-2) for 72 h,and the steady transdermal rate was 4.4512,2.3945μg·cm^(-2)·h^(-1).The infiltration multiple was 4.2550 and 1.7464.CONCLUSION The best penetration enhancer of post-crosslinking Daphnes Giraldii Cortex gel plaster is 1%menthol,1%borneol and 2%camphor.

关 键 词：祖师麻 后交联凝胶贴膏 经皮渗透 促渗剂 祖师麻甲素 

分 类 号：R283[医药卫生—中药学]