基于氧化石墨烯功能化锥形光纤的血红蛋白传感研究  

Study on Hemoglobin Sensing by Graphene Oxide Functionalized Tapered Optical Fiber

作　　者：刘壮 杨玲珍 王娟芬 冯纪鑫 刘娇娇 姜琦 Liu Zhuang;Yang Lingzhen;Wang Juanfen;Feng Jixin;Liu Jiaojiao;Jiang Qi(College of Physics and Optoelectronics,Taiyuan University of Technology,Taiyuan 030024,Shanxi,China;Key Lab of Advanced Transducers and Intelligent Control System,Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,Shanxi,China)

机构地区：[1]太原理工大学物理与光电工程学院,山西太原030024 [2]太原理工大学新型传感器与智能控制教育部重点实验室,山西太原030024

出　　处：《激光与光电子学进展》2023年第5期211-216,共6页Laser & Optoelectronics Progress

基　　金：国家自然科学基金(61975141,61575137,61675144)。

摘　　要：通过混沌相关光纤环衰荡传感系统实时监测氧化石墨烯沉积过程,并采用氧化石墨烯功能化锥形光纤作为传感元件对血红蛋白传感进行了实验研究。通过实时监测氧化石墨烯对锥形光纤功能化过程中衰荡时间的变化,分析了功能化过程中锥形光纤表面羟基化、硅烷化和氧化石墨烯沉积对光传输损耗的影响。通过扫描电子显微镜对氧化石墨烯功能化锥形光纤效果进行检测。研究了不同浓度的氧化石墨烯功能化锥形光纤作为传感元件时对血红蛋白传感灵敏度的影响,实验结果表明:与未功能化锥形光纤相比,使用氧化石墨烯功能化锥形光纤进行血红蛋白传感,灵敏度提高了一个数量级。在功能化过程中,氧化石墨烯浓度将影响功能化后锥形光纤的传感灵敏度,且随着浓度的增加传感灵敏度增强。该研究成果有望在生物传感领域得到应用。In this study,the functionalization of a tapered optical fiber using graphene oxide is monitored in real time by a chaotic correlation fiber loop ringdown system,and hemoglobin sensing is achieved experimentally with the functionalized graphene oxide tapered optical fiber as the sensor element.The functionalization of the tapered optical fiber surface using graphene oxide can be divided into hydroxylation,silanization,and grapheneoxide deposition.The effect of transmission loss is analyzed during functionalization according to the change in the ringdown time.The functionalized tapered optical fiber is tested via scanning electron microscopy.Moreover,the sensitivity of hemoglobin sensing is evaluated using different concentrations of graphene oxide in the functionalization process.The experimental results show that the functionalized tapered optical fiber exhibits a considerable increase in sensitivity by an order of magnitude compared with the unfunctionalized tapered optical fiber.The sensitivity of the functionalized tapered optical fiber is influenced by the concentration of graphene oxide during functionalization;sensitivity increases with concentration.These results can potentially be applied in the field of biosensing.

关 键 词：医用光学与生物技术 锥形光纤 氧化石墨烯 光纤环衰荡 血红蛋白 传感 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]