白花蛇舌草乙酸乙酯部位的化学成分研究  

Study on Chemical Constituents from Ethyl Acetate Soluble Part of Hedyotis Diffusa Willd

作　　者：张丽[1] 刘海霞[1] 牟晓红 王玉璞 ZHANG Li;LIU Hai-xia;MOU Xiao-hong;WANG Yu-pu(School of Chemical Engineering,Lanzhou City University,Lanzhou Gansu 730070)

机构地区：[1]兰州城市学院化学工程学院,甘肃兰州730070

出　　处：《甘肃高师学报》2023年第2期16-19,共4页Journal of Gansu Normal Colleges

基　　金：甘肃省科技厅省级科技计划(创新基地和人才计划)项目“鱼腥草中抗病毒成分的发现及其抗病毒作用机制研究”(20JR10RA293);甘肃省科技厅省级科技计划(创新基地和人才计划)项目“基于电纺功能性纳米纤维固相萃取体系的构建及其典型污染物的分析检测”(20JR5RA208);甘肃省教育厅高等学校创新基金项目“白花蛇舌草中抗过敏成分的发现及其作用机制研究”(2020A-127).

摘　　要：采用硅胶、大孔树脂、葡聚糖凝胶、MCI树脂以及高效液相半制备色谱等色谱分离方法,从茜草科耳草属的白花蛇舌草95%乙醇提取物的乙酸乙酯萃取部位分离出9个化合物,运用核磁共振等波谱技术和文献对比法鉴定了9个化合物的结构,分别为:毛地黄内酯(1),琥珀酸二甲酯(2),琥珀酸二乙酯(3),5-(羟甲基)-2-糠醛(4),香草醛(5),对羟基苯甲酸乙酯(6),4-甲氧基苯-1, 2-二醇(7),香草酸(8),东莨菪内酯(9).化合物1是降11碳倍半萜,化合物2和3是链状羧酸酯类衍生物,化合物1—3为首次从该植物中分离得到.Nine compounds were isolated from the ethyl acetate soluble part of 95%ethanol extract of Hedyotis diffusa of the genus Hedyotis(Rubiaceae)by silica gel,macroporous resin,sephadex LH,20,MCI resin and high performance liquid separation chromato,graphy techniques.The structures of the nine compounds were identified by means of NMR spectroscopy and literature comparison,including loliolide(1),dimethyl succinate(2),diethyl succinate(3),5,(hydroxymethyl),2,furfuraldehyde(4),vanillin(5),ethyl 4,hy,droxybenzoate(6),4,methoxybenzene,1,2,dio(7),vanillic acid(8),scopoletin(9).Compound 1 is a nor-sesquiterpene with 11 car,bons on the skeleton,and compounds 2 and 3 are chain carboxylic ester derivatives.Compounds 1—3 were partially isolated from Hedyotis diffusa for the first time.

关 键 词：白花蛇舌草 化学成分 乙酸乙酯部位 毛地黄内酯 琥珀酸二酯 

分 类 号：O629[理学—有机化学]